ArticlePhysiological genomics2011
MicroRNAs as new maestro conducting the expanding symphony orchestra of regenerative and reparative medicine.
Article in Physiological genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- A novel endosome-escaping, macrophage-targeted nanoparticle platform for miR-146a delivery with favorable in vivo biodistribution and biocompatibility.bioRxiv : the preprint server for biology · 2026Article
- Endosome-escaping engineered LNP-miR146a with in vivo biodistribution to mitigate inflammation and foreign body giant cell formation.bioRxiv : the preprint server for biology · 2026Article
- Macrophage microRNA-146a is a central regulator of the foreign body response to biomaterial implants.Biomaterials · 2025Article
- Identification of a miRNA Panel with a Potential Determinant Role in Patients Suffering from Periodontitis.Current issues in molecular biology · 2023Article
- Electro-Acupuncture Promotes the Differentiation of Endogenous Neural Stem Cells via Exosomal microRNA 146b After Ischemic Stroke.Frontiers in cellular neuroscience · 2020Article
- Role of miRNAs in hypoxia-related disorders.Journal of biosciences · 2018Review
- Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting.Journal of visualized experiments : JoVE · 2018Article
- Exosome Therapy for Stroke.Stroke · 2018Review
- Profiling the circulating miRnome reveals a temporal regulation of the bone injury response.Theranostics · 2018Article
- Epigenetics in heart failure phenotypes.BBA clinical · 2016Review
- Magnet-Bead Based MicroRNA Delivery System to Modify CD133Stem cells international · 2016Article
- microRNA-200b as a Switch for Inducible Adult Angiogenesis.Antioxidants & redox signaling · 2015Review
- Gene therapy for bone engineering.Frontiers in bioengineering and biotechnology · 2015Review
- Micro-RNAs in regenerating lungs: an integrative systems biology analysis of murine influenza pneumonia.BMC genomics · 2014Article
- Engulfment of apoptotic cells by macrophages: a role of microRNA-21 in the resolution of wound inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Neurorestorative therapy for stroke.Frontiers in human neuroscience · 2014Review
- miR-141 as a regulator of the mitochondrial phosphate carrier (Slc25a3) in the type 1 diabetic heart.American journal of physiology. Cell physiology · 2012Article
- miR-210: the master hypoxamir.Microcirculation (New York, N.Y. : 1994) · 2012Review
- miRNA in wound inflammation and angiogenesis.Microcirculation (New York, N.Y. : 1994) · 2012Review
- Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis.Journal of cellular and molecular medicine · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The human genome encodes 1,048 microRNAs (miRNAs). These miRNAs regulate virtually all biological processes. Leaving ignominy on the significance miRNAs behind we are approaching a new era in tissue repair where an ever expanding orchestra of events that enable tissue repair and regeneration seems to be conducted by miRNAs as the maestro. microRNAs are emerging as molecular rheostats that fine-tune and switch regulatory circuits governing tissue repair. Key elements of tissue repair such as stem cell biology, inflammation, hypoxia-response, and angiogenesis are all under the sophisticated control of a network of specific mRNAs. Embryonic stem cells lacking miRNAs lose their "stemness." Manipulation of specific cellular miRNAs helps enhance reprogramming of somatic cells to an embryonic stem cell-like phenotype helping generate inducible pluripotent stem cells. Expression of miRNAs is subject to control by epigenetic factors. Such control influences the balance between proliferation and differentiation of stem cells. Angiomirs regulate various aspects of angiogenesis, such as proliferation, migration, and morphogenesis of endothelial cells. MiRNAs play a key role in resolution of inflammation. Hypoxia-inducible mRNAs or hypoxamirs suppress mitochondrial respiration, cause cell cycle arrest, and interfere with growth factor signaling. miRNA-210 is a good example in this category that impairs wound closure. As fine tools enabling specific and temporally controlled manipulation of cell-specific miRNAs emerge, miRNA-based therapies hold promise in facilitating tissue repair. Treatment of skin wounds has lower barriers because it lends itself to local delivery of miRNA mimics and antagonizing agents minimizing risks associated with systemic off-target toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.