ArticleCritical care (London, England)2011
Activation of factor VII-activating protease in human inflammation: a sensor for cell death.
Article in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
- Association of circulating factor seven activating protease (FSAP) and of oral Omega-3 fatty acids supplements with clinical outcome in patients with atrial fibrillation: the OMEGA-AF study.Journal of thrombosis and thrombolysis · 2014Trial
- Factor VII Activating Protease (FSAP) and Its Importance in Hemostasis-Part I: FSAP Structure, Synthesis and Activity Regulation: A Narrative Review.International journal of molecular sciences · 2023Review
- Identification of a Phage Display-Derived Peptide Interacting with the N-Terminal Region of Factor VII Activating Protease (FSAP) Enables Characterization of Zymogen Activation.ACS chemical biology · 2022Article
- The role of extracellular DNA (exDNA) in cellular processes.Cancer biology & therapy · 2021Review
- Factor VII Activating Protease Expression in Human Platelets and Accumulation in Symptomatic Carotid Plaque.Journal of the American Heart Association · 2020Article
- Expression of the Marburg I Single Nucleotide Polymorphism (MI-SNP) and the Marburg II Single Nucleotide Polymorphism (MII-SNP) of the Factor VII-Activating Protease (FSAP) Gene and Risk of Coronary Artery Disease (CAD): A Pilot Study in a Single Population.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- DNA and factor VII-activating protease protect against the cytotoxicity of histones.Blood advances · 2017Article
- Neutrophil extracellular traps in patients with pulmonary tuberculosis.Respiratory research · 2017Article
- Transforming Growth Factor-β (TGF-β) Inhibits the Expression of Factor VII-activating Protease (FSAP) in Hepatocytes.The Journal of biological chemistry · 2016Article
- Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos.PLoS neglected tropical diseases · 2015Article
- Diabetes-independent increase of factor VII-activating protease activation in patients with Gram-negative sepsis (melioidosis).Journal of thrombosis and haemostasis : JTH · 2015Observational
- Complement, thrombotic microangiopathy and disseminated intravascular coagulation.Journal of intensive care · 2014Review
- C1-inhibitor efficiently inhibits Escherichia coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood.Clinical and experimental immunology · 2013Article
- The factor VII-activating protease (FSAP) enhances the activity of bone morphogenetic protein-2 (BMP-2).The Journal of biological chemistry · 2013Article
- Tissue factor pathway inhibitor is an inhibitor of factor VII-activating protease.Journal of thrombosis and haemostasis : JTH · 2012Article
- Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCell death is a central event in the pathogenesis of sepsis and is reflected by circulating nucleosomes. Circulating nucleosomes were suggested to play an important role in inflammation and were demonstrated to correlate with severity and outcome in sepsis patients. We recently showed that plasma can release nucleosomes from late apoptotic cells. Factor VII-activating protease (FSAP) was identified to be the plasma serine protease responsible for nucleosome release. The aim of this study was to investigate FSAP activation in patients suffering from various inflammatory diseases of increasing severity.
methodsWe developed ELISAs to measure FSAP-C1-inhibitor and FSAP-α2-antiplasmin complexes in plasma. FSAP-inhibitor complexes were measured in the plasma of 20 adult patients undergoing transhiatal esophagectomy, 32 adult patients suffering from severe sepsis and 8 from septic shock and 38 children suffering from meningococcal sepsis.
resultsWe demonstrate plasma FSAP to be activated upon contact with apoptotic and necrotic cells by an assay detecting complexes between FSAP and its target serpins α2-antiplasmin and C1-inhibitor, respectively. By means of that assay we demonstrate FSAP activation in post-surgery patients, patients suffering from severe sepsis, septic shock and meningococcal sepsis. Levels of FSAP-inhibitor complexes correlate with nucleosome levels and correlate with severity and mortality in these patients.
conclusionsThese results suggest FSAP activation to be a sensor for cell death in the circulation and that FSAP activation in sepsis might be involved in nucleosome release, thereby contributing to lethality.
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