ArticleJournal of anatomy2011
The organisation of elastin and fibrillins 1 and 2 in the cruciate ligament complex.
Article in Journal of anatomy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Review
- The role of mechanotransduction in tendon.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Review
- Age-related changes in microRNAs expression in cruciate ligaments of wild-stock house mice.Physiological reports · 2022Article
- Proteoglycans play a role in the viscoelastic behaviour of the canine cranial cruciate ligament.Frontiers in bioengineering and biotechnology · 2022Article
- Near infrared spectroscopic evaluation of biochemical and crimp properties of knee joint ligaments and patellar tendon.PloS one · 2022Article
- Structure, composition and fibril-reinforced poroviscoelastic properties of bovine knee ligaments and patellar tendon.Journal of the Royal Society, Interface · 2021Article
- Elastic fibers in orthopedics: Form and function in tendons and ligaments, clinical implications, and future directions.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- Force Transmission Between the Gastrocnemius and Soleus Sub-Tendons of the Achilles Tendon in Rat.Frontiers in bioengineering and biotechnology · 2020Article
- Variations in internal structure, composition and protein distribution between intra- and extra-articular knee ligaments and tendons.Journal of anatomy · 2018Article
- Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing.Scientific reports · 2017Article
- Distribution of proteins within different compartments of tendon varies according to tendon type.Journal of anatomy · 2016Article
- Fibrillins in Tendon.Frontiers in aging neuroscience · 2016Review
- The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons.Journal of the mechanical behavior of biomedical materials · 2015Article
- Elastin governs the mechanical response of medial collateral ligament under shear and transverse tensile loading.Acta biomaterialia · 2015Article
- Elastin content is high in the canine cruciate ligament and is associated with degeneration.Veterinary journal (London, England : 1997) · 2014Article
- The role of the non-collagenous matrix in tendon function.International journal of experimental pathology · 2013Review
- Effect of elastin digestion on the quasi-static tensile response of medial collateral ligament.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2013Article
- Elastic fibres are broadly distributed in tendon and highly localized around tenocytes.Journal of anatomy · 2013Article
- Specialization of tendon mechanical properties results from interfascicular differences.Journal of the Royal Society, Interface · 2012Article
- The distribution of fibrillin-2 and LTBP-2, and their co-localisation with fibrillin-1 in adult bovine tail disc.Journal of anatomy · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although elastin fibres and oxytalan fibres (bundles of microfibrils) have important mechanical, biochemical and cell regulatory functions, neither their distribution nor their function in cruciate ligaments has been investigated. Twelve pairs of cruciate ligaments (CLs) were obtained from 10 adult dogs with no evidence of knee osteoarthritis. Elastic fibres were identified using Verhoeff's and Miller's staining. Fibrillins 1 and 2 were immunolocalised and imaged using confocal laser scanning microscopy. Hydrated, unfixed tissue was analysed using Nomarski differential interference microscopy (NDIC), allowing structural and mechanical analysis. Microfibrils and elastin fibres were widespread in both CLs, predominantly within ligament fascicles, parallel to collagen bundles. Although elastin fibres were sparse, microfibrils were abundant. We described abundant fibres composed of both fibrillin 1 and fibrillin 2, which had a similar pattern of distribution to oxytalan fibres. NDIC demonstrated complex interfascicular and interbundle anatomy in the CL complex. The distribution of elastin fibres is suggestive of a mechanical role in bundle reorganisation following ligament deformation. The presence and location of fibrillin 2 in oxytalan fibres in ligament differs from the solely fibrillin 1-containing oxytalan fibres previously described in tendon and may demonstrate a fundamental difference between ligament and tendon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.