Evidence map›Paper›PMID 21466281›Full record

ArticleHybridoma (2005)2011

Characterization of monoclonal antibodies to the plasma cell alloantigen ENPP1.

Sadia Abbasi, Dong-Mi Shin, Natalie Beaty, Marek Masiuk, Sophia Chen, Ines Gonzalez-Garcia, Ming Zhao, James Goding, Herbert C Morse, Hongsheng Wang

Open access · greenAbstract read
In one paragraph

Article in Hybridoma (2005), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. ENPP1 Immunobiology as a Therapeutic Target.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. New insights into heterogeneity of peritoneal B-1a cells.Annals of the New York Academy of Sciences · 2015
    Review
  8. Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions.Proceedings of the National Academy of Sciences of the United States of America · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Sadia AbbasiLaboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20850, USA.
Dong-Mi Shin
Natalie Beaty
Marek Masiuk
Sophia Chen
Ines Gonzalez-Garcia
Ming Zhao
James Goding
Herbert C Morse
Hongsheng Wang
National Institutes of Health · USAustralian Regenerative Medicine Institute · AU

Funding

Molecular Regulation of B-Cell Differentiation and FunctionZIAAI001024 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MORSE, HERBERT · 2009 to 2018
$8.3M
Lymphomas And Retroviral PathogenesisZIAAI000858 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MORSE, HERBERT · 2009 to 2018
$5.3M
Intramural NIH HHS
6 · The paper itself

Abstract

The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) has documented roles in mineralization, nucleotide recycling, and insulin resistance. While ENPP1 was first identified as an alloantigen on mouse plasma cells (PCs), later studies revealed expression in many tissues. Previously described monoclonal antibodies against ENPP1 expressed at the cell surface recognized cells only from mice bearing the a allotype, ENPP1(a), precluding studies of mice bearing the alternative allele, ENPP1(b). Here, we characterize a novel anti-ENPP1 monoclonal antibody that recognizes both alleles and can be used for flow cytometry.

Indexed as

Amino Acid SequenceAnimalsAntibodies, MonoclonalAntibody SpecificityChromatography, LiquidFlow CytometryImmunoglobulin AllotypesImmunoprecipitationIsoantigensMass SpectrometryMiceMice, Inbred C57BLMolecular Sequence DataPhosphoric Diester HydrolasesPyrophosphatasesAntibodies, Monoclonalectonucleotide pyrophosphatase phosphodiesterase 1Immunoglobulin AllotypesIsoantigensPhosphoric Diester HydrolasesPyrophosphatases

Identifiers

PMID21466281
PMCPMC3119333
OpenAlexW2134122977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.