Evidence map›Paper›PMID 21465668›Full record

ReviewDevelopmental neurobiology2012

Imaging adhesion and signaling dynamics in Xenopus laevis growth cones.

Miguel Santiago-Medina, Jonathan P Myers, Timothy M Gomez

Abstract readReview
In one paragraph

Review in Developmental neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Reduced cell-substrate adhesion formation promotes cell migration inbioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Calpain-Mediated Proteolysis of Talin and FAK Regulates Adhesion Dynamics Necessary for Axon Guidance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  8. Review
  9. Review
  10. Guidance of Axons by Local Coupling of Retrograde Flow to Point Contact Adhesions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Neural Explant Cultures from Xenopus laevis.Journal of visualized experiments : JoVE · 2012
    Article
  16. Article
  17. Focal adhesion kinase promotes integrin adhesion dynamics necessary for chemotropic turning of nerve growth cones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Miguel Santiago-MedinaDepartment of Neuroscience, Neuroscience Training Program, University of Wisconsin-Madison, WI 53706, USA.
Jonathan P Myers
Timothy M Gomez
University of Wisconsin–Madison · US

Funding

INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
Regulation of Axon Guidance by Second MessengersR01NS041564 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI GOMEZ, TIMOTHY M · 2000 to 2013
$3.4M
Regulation of Axon Guidance by Second MessengerR56NS041564 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI GOMEZ, TIMOTHY M · 2015 to 2015
$374k
NIGMS NIH HHS T32 GM008692NINDS NIH HHS NS41564NINDS NIH HHS R01 NS041564NINDS NIH HHS R56 NS041564
6 · The paper itself

Abstract

Xenopus laevis provides a robust model system to study cellular signaling and downstream processes during development both in vitro and in vivo. Intracellular signals must function within highly restricted spatial and temporal domains to activate specific downstream targets and cellular processes. Combining the versatility of developing Xenopus neurons with advances in fluorescent protein biosensors and imaging technologies has allowed many dynamic cellular processes to be visualized. This review will focus on the techniques we use to visualize and measure cell signaling, motility and adhesion by quantitative fluorescence microscopy in vitro and in vivo.

Indexed as

AnimalsCell AdhesionCell MovementGrowth ConesImaging, Three-DimensionalNeurogenesisNeuronsSignal TransductionXenopus laevis

Identifiers

PMID21465668
PMCPMC3158960
OpenAlexW1981238553

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.