Evidence map›Paper›PMID 21465637›Full record

GuidelinePediatric blood & cancer2011

Guideline for the classification of the acute emetogenic potential of antineoplastic medication in pediatric cancer patients.

L Lee Dupuis, Sabrina Boodhan, Lillian Sung, Carol Portwine, Richard Hain, Patricia McCarthy, Mark Holdsworth, Pediatric Oncology Group of Ontario

Open access · bronzeAbstract readConsensus StatementPractice GuidelineReview
In one paragraph

Guideline in Pediatric blood & cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Antiemetic medications for preventing chemotherapy-induced nausea and vomiting in children: a systematic review and Bayesian network meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  2. Pooled it
  3. Guideline
  4. Trial
  5. Trial
  6. Aprepitant as an add-on therapy in children receiving highly emetogenic chemotherapy: a randomized, double-blind, placebo-controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015
    Trial
  7. Palonosetron in pediatric patients: A single-center, retrospective evaluation of policy and clinical practice guideline discordance.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Creation of a chemotherapy-induced nausea/vomiting dashboard to improve outcomes for pediatric cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
  16. Article
  17. Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2021
    Article
  18. Article
  19. Guideline concordant care for prevention of acute chemotherapy-induced nausea and vomiting in children, adolescents, and young adults.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

L Lee DupuisDepartment of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada. lee.dupuis@sickkids.ca
Sabrina Boodhan
Lillian Sung
Carol Portwine
Richard Hain
Patricia McCarthy
Mark Holdsworth
Pediatric Oncology Group of Ontario
University of Toronto · CAChildren's Hospital of Eastern Ontario · CAHospital for Sick Children · CAMcMaster University · CAUniversity Hospital of Wales · GBUniversity of New Mexico · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

This guideline provides clinicians caring for children with an approach to assessing the acute emetogenic potential of antineoplastic therapies. It was developed by an international, inter-professional panel of clinicians and researchers using AGREE and CAN-ADAPTE methods. The emetogenicity of antineoplastic agents was evaluated and ranked as high, moderate, low, or minimal. The emetogenicity of multiple-agent and multiple-day antineoplastic therapy was also classified. Gaps in the evidence used to underpin the guideline recommendations were identified. The contribution of this guideline to the prevention of antineoplastic-induced nausea and vomiting in individual children about to receive antineoplastic therapy requires prospective evaluation.

Indexed as

AdolescentAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsChildChild, PreschoolHumansInfantNauseaNeoplasmsRisk AssessmentVomitingAntineoplastic Agents

Identifiers

PMID21465637
PMCPMC6554029
OpenAlexW2070653328

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.