ArticleJournal of cellular biochemistry2011
Resistance to paclitaxel increases the sensitivity to other microenvironmental stresses in prostate cancer cells.
Article in Journal of cellular biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Dual Targeting Strategy: Colchicine and Paclitaxel Combination Against Prostate Cancer Cells Colchicine-Paclitaxel Synergy in Prostate Cancer.Medeniyet medical journal · 2026Article
- Preclinical Toxicity and Pharmacokinetic Evaluation of Paclitaxel Nanodispersion.AAPS PharmSciTech · 2025Article
- Dynamic release of extracellular particles after opening of the blood-brain barrier predicts glioblastoma susceptibility to paclitaxel.Nature communications · 2025Article
- Expanding paclitaxel's therapeutic window: Investigating the pharmacokinetic, clinical formulation and mechanistic aspects of paclitaxel‑lipoate conjugate.Oncology letters · 2025Article
- BMP signaling inhibition overcomes chemoresistance of prostate cancer.American journal of cancer research · 2023Article
- Role of extracellular vesicles secretion in paclitaxel resistance of prostate cancer cells.Cancer drug resistance (Alhambra, Calif.) · 2022Article
- Paclitaxel resistance and the role of miRNAs in prostate cancer cell lines.World journal of urology · 2019Article
- Review
- Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration.BMC cancer · 2017Article
- A novel spontaneous model of epithelial-mesenchymal transition (EMT) using a primary prostate cancer derived cell line demonstrating distinct stem-like characteristics.Scientific reports · 2017Article
- Slug contributes to cancer progression by direct regulation of ERα signaling pathway.International journal of oncology · 2015Article
- The presence of androgen receptor elements regulates ZEB1 expression in the absence of androgen receptor.Journal of cellular biochemistry · 2015Article
- CETN1 is a cancer testis antigen with expression in prostate and pancreatic cancers.Biomarker research · 2013Article
- Acquisition of paclitaxel resistance is associated with a more aggressive and invasive phenotype in prostate cancer.Journal of cellular biochemistry · 2013Article
- Changing the energy habitat of the cancer cell in order to impact therapeutic resistance.Molecular pharmaceutics · 2011Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The microenvironment is central to many aspects of cancer pathobiology and has been proposed to play a role in the development of cancer cell resistance to therapy. To examine the response to microenvironmental conditions, two paclitaxel resistant prostate cancer (PCa) cell lines (stable and reversible) and one reversible heat resistant cell line were studied. In comparison to their parental cell lines, both paclitaxel resistant cell lines (stable and reversible) were more sensitive to microenvironmental heat, potentially yielding a synergistic therapeutic opportunity. In the two phenotypic cells repopulated after acute heat or paclitaxel treatments, there was an inverse correlation between paclitaxel and heat resistance: resistance to paclitaxel imparted sensitivity to heat; resistance to heat imparted sensitivity to paclitaxel. These studies indicate that as cancer cells evolve resistance to single microenvironmental stress they may be more sensitive to others, perhaps allowing us to design new approaches for PCa therapy.
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