ArticleJournal of thrombosis and thrombolysis2011
The association of L-selectin polymorphisms with L-selectin serum levels and risk of ischemic stroke.
Article in Journal of thrombosis and thrombolysis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- An rs4705342 T>C polymorphism in the promoter of miR-143/145 is associated with a decreased risk of ischemic stroke.Scientific reports · 2016Trial
- Higher Levels of Cardiovascular Biomarkers Following Hypertensive Compared to Normotensive Pregnancy.Pregnancy (Hoboken, N.J.) · 2025Article
- Effects of cold stress on the blood-brain barrier in Plectropomus leopardus.BMC genomics · 2024Article
- Novel CSF biomarkers for diagnosis and integrated analysis of neuropsychiatric systemic lupus erythematosus: based on antibody profiling.Arthritis research & therapy · 2023Article
- Review
- Inflammatory biomarkers of ischemic stroke.Internal and emergency medicine · 2023Review
- DIA-based technology explores hub pathways and biomarkers of neurological recovery in ischemic stroke after rehabilitation.Frontiers in neurology · 2023Article
- Article
- Search for Reliable Circulating Biomarkers to Predict Carotid Plaque Vulnerability.International journal of molecular sciences · 2020Review
- A functional polymorphism in the promoter of TUG1 is associated with an increased risk of ischaemic stroke.Journal of cellular and molecular medicine · 2019Article
- Comparison of L-selectin blood level and gene polymorphism in tuberculosis patients with healthy individuals.Journal of clinical laboratory analysis · 2018Article
- Deregulated microRNA and mRNA expression profiles in the peripheral blood of patients with Marfan syndrome.Journal of translational medicine · 2018Article
- A head-to-tail view of L-selectin and its impact on neutrophil behaviour.Cell and tissue research · 2018Review
- Soluble L-Selectin as an Independent Biomarker of Bronchial Asthma.Journal of clinical laboratory analysis · 2015Article
- Multi-ethnic analysis reveals soluble L-selectin may be post-transcriptionally regulated by 3'UTR polymorphism: the Multi-Ethnic Study of Atherosclerosis (MESA).Human genetics · 2015Article
- Plasma and serum L-selectin and clinical and subclinical cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis (MESA).Translational research : the journal of laboratory and clinical medicine · 2014Article
- Toll-Like Receptor induced CD11b and L-selectin response in patients with coronary artery disease.PloS one · 2013Article
- Association between cytochrome P450 promoter polymorphisms and ischemic stroke.Experimental and therapeutic medicine · 2012Article
- Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles.Progress in neurobiologyReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
L-selectin is a member of the selectin family of cell adhesion molecules which are important in the transient attachment of leukocytes to endothelial cells, which plays a role in inflammation processes and is one of the earliest events in the pathogenesis of atherosclerosis. No studies have examined the association of this polymorphism with ischemic stroke. Therefore, we investigated that L-selectin gene polymorphism and its soluble level are associated with ischemic stroke in Chinese population. We analyzed single nucleotide polymorphisms of L-selectin gene Pro213Ser (P213S) in 265 patients with ischemic stroke and 280 age and sex matched controls, using PCR-RFLP and DNA sequencing method, while soluble L-selectin levels were measured by ELISA. There were significant differences in the genotype and allele frequencies of L-selectin gene P213S polymorphism between the group of patients with ischemic stroke and the control group (P < 0.05). Soluble L-selectin levels were increased in patients with ischemic stroke compared with controls (P < 0.01). Moreover, The P213S polymorphism of L-selectin was significantly associated with sL-selectin levels, the serum levels of L-selectin PP genotype carriers was significantly higher than no carriers in patients with ischemic stroke (P < 0.05). The P213S polymorphism of L-selectin and its sL-selectin levels are associated with ischemic stroke in Chinese population. Our data suggests that L-selectin gene may play a role in the development of ischemic stroke.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.