ArticleAnalytical and bioanalytical chemistry2011
Nonlinear interferometric vibrational imaging for fast label-free visualization of molecular domains in skin.
Article in Analytical and bioanalytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The application of label-free imaging technologies in transdermal research for deeper mechanism revealing.Asian journal of pharmaceutical sciences · 2021Review
- Tracking the formation and degradation of fatty-acid-accumulated mitochondria using label-free chemical imaging.Scientific reports · 2021Article
- Quantitative characterization of mechanically indented in vivo human skin in adults and infants using optical coherence tomography.Journal of biomedical optics · 2017Article
- The Gold Nanorod-Biology Interface: From Proteins to Cells to Tissue.Current physical chemistry · 2013Article
- Characterization of cholesterol crystals in atherosclerotic plaques using stimulated Raman scattering and second-harmonic generation microscopy.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The most prevalent molecular constituents of skin are spatially mapped by the use of nonlinear interferometric vibrational imaging, a coherent anti-Stokes Raman scattering (CARS)-based technique. Raman-like profiles over the range from 2,800 to 3,000 cm(-1) are acquired by means of completely suppressing the non-resonant background, allowing the generation of images based on the molecule-specific spectral profiles over the probed region with high spatial resolution. A simple algorithm that maps spectral content to color allows the visualization of histology in a manner analogous to that obtained with more conventional staining procedures (e.g., hematoxylin-eosin), but faster and with the benefit of having access to localized spectra, which could further enhance the potential for diagnosis of diseases, especially during the early stages of development.
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Registered trials
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