ArticlePloS one2011
Similarity in recombination rate estimates highly correlates with genetic differentiation in humans.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Approximate Bayesian computational methods to estimate the strength of divergent selection in population genomics models.Journal of Computational Mathematics and Data Science · 2024Article
- Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits.Genome research · 2020Article
- From molecules to populations: appreciating and estimating recombination rate variation.Nature reviews. Genetics · 2020Review
- Exploration of fine-scale recombination rate variation in the domestic horse.Genome research · 2019Article
- Mapping Recombination Rate on the Autosomal Chromosomes Based on the Persistency of Linkage Disequilibrium Phase Among Autochthonous Beef Cattle Populations in Spain.Frontiers in genetics · 2019Article
- The Time Scale of Recombination Rate Evolution in Great Apes.Molecular biology and evolution · 2016Article
- Population-specific common SNPs reflect demographic histories and highlight regions of genomic plasticity with functional relevance.BMC genomics · 2014Article
- The 8p23 inversion polymorphism determines local recombination heterogeneity across human populations.Genome biology and evolution · 2014Article
- Reconstructing past changes in locus-specific recombination rates.BMC genetics · 2013Article
- Population demographic history can cause the appearance of recombination hotspots.American journal of human genetics · 2012Article
- Recombination rates in admixed individuals identified by ancestry-based inference.Nature genetics · 2011Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombination varies greatly among species, as illustrated by the poor conservation of the recombination landscape between humans and chimpanzees. Thus, shorter evolutionary time frames are needed to understand the evolution of recombination. Here, we analyze its recent evolution in humans. We calculated the recombination rates between adjacent pairs of 636,933 common single-nucleotide polymorphism loci in 28 worldwide human populations and analyzed them in relation to genetic distances between populations. We found a strong and highly significant correlation between similarity in the recombination rates corrected for effective population size and genetic differentiation between populations. This correlation is observed at the genome-wide level, but also for each chromosome and when genetic distances and recombination similarities are calculated independently from different parts of the genome. Moreover, and more relevant, this relationship is robustly maintained when considering presence/absence of recombination hotspots. Simulations show that this correlation cannot be explained by biases in the inference of recombination rates caused by haplotype sharing among similar populations. This result indicates a rapid pace of evolution of recombination, within the time span of differentiation of modern humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.