ArticlePloS one2011
Variations on fibrinogen-erythrocyte interactions during cell aging.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
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- A mathematical model of fibrinogen-mediated erythrocyte-erythrocyte adhesion.Communications biology · 2023Article
- 2,3-Diphosphoglycerate and the Protective Effect of Pyruvate Kinase Deficiency against Malaria Infection-Exploring the Role of the Red Blood Cell Membrane.International journal of molecular sciences · 2023Article
- A mechanistic model of cross-bridge migration in RBC aggregation and disaggregation.Frontiers in bioengineering and biotechnology · 2022Article
- Innate coagulability changes with age in stored packed red blood cells.Thrombosis research · 2020Article
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- Red blood cell adhesion to ICAM-1 is mediated by fibrinogen and is associated with right-to-left shunts in sickle cell disease.Blood advances · 2020Article
- Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes.International journal of molecular sciences · 2020Review
- Oxidative Stress and Thrombosis during Aging: The Roles of Oxidative Stress in RBCs in Venous Thrombosis.International journal of molecular sciences · 2020Review
- Fibrinogen and LDL Influence on Blood Viscosity and Outcome of Acute Ischemic Stroke Patients in Indonesia.Annals of neurosciences · 2019Article
- Red blood cells: the forgotten player in hemostasis and thrombosis.Journal of thrombosis and haemostasis : JTH · 2019Review
- West Nile Virus Capsid Protein Interacts With Biologically Relevant Host Lipid Systems.Frontiers in cellular and infection microbiology · 2019Article
- TheInternational journal of nanomedicine · 2018Article
- Role of red blood cells in haemostasis and thrombosis.ISBT science series · 2017Article
- Atomic force microscopy as a tool to evaluate the risk of cardiovascular diseases in patients.Nature nanotechnology · 2016Article
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- Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium ion dependent and is mediated by LD surface proteins.Journal of virology · 2012Article
- Translocating the blood-brain barrier using electrostatics.Frontiers in cellular neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erythrocyte hyperaggregation, a cardiovascular risk factor, is considered to be caused by an increase in plasma adhesion proteins, particularly fibrinogen. We have recently reported a specific binding between fibrinogen and an erythrocyte integrin receptor with a β(3) or β(3)-like subunit. In this study we evaluate the influence of erythrocyte aging on the fibrinogen binding. By atomic force microscopy-based force spectroscopy measurements we found that increasing erythrocyte age, there is a decrease of the binding to fibrinogen by decreasing the frequency of its occurrence but not its force. This observation is reinforced by zeta-potential and fluorescence spectroscopy measurements. We conclude that upon erythrocyte aging the number of fibrinogen molecules bound to each cell decreases significantly, due to the progressive impairment of the specific fibrinogen-erythrocyte receptor interaction. Knowing that younger erythrocytes bind more to fibrinogen, we could presume that this population is the main contributor to the cardiovascular diseases associated with increased fibrinogen content in blood, which could disturb the blood flow. Our data also show that the sialic acids exposed on the erythrocyte membrane contribute for the interaction with fibrinogen, possibly by facilitating its binding to the erythrocyte membrane receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.