ArticleInfection and immunity2011
Persistent nasal carriage of Staphylococcus aureus is associated with deficient induction of human beta-defensin 3 after sterile wounding of healthy skin in vivo.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06731881 (Leveraging Photodynamic Therapy to Inhibit Microorganisms - Assessing the Efficacy of Photodynamic Therapy for Preventing Surgical Site Infections in Nasal Surgery Patients), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Leveraging Photodynamic Therapy to Inhibit Microorganisms - Assessing the Efficacy of Photodynamic Therapy for Preventing Surgical Site Infections in Nasal Surgery Patients: A Pilot Study
Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population.PloS one · 2019Trial
- Comparison of the bacterial microbiome in the pharynx and nasal cavity of persistent, intermittent carriers and non-carriers ofJournal of medical microbiology · 2024Article
- Unveiling the Relevance of the Oral Cavity as aPathogens (Basel, Switzerland) · 2023Article
- Multilocus sequence type-dependent activity of human and animal cathelicidins against community-, hospital-, and livestock-associated methicillin-resistantJournal of animal science and technology · 2022Article
- Inflammatory Response AgainstFrontiers in immunology · 2022Article
- Novel Functions and Signaling Specificity for the GraS Sensor Kinase of Staphylococcus aureus in Response to Acidic pH.Journal of bacteriology · 2020Article
- Inhibition of the ATP synthase sensitizes Staphylococcus aureus towards human antimicrobial peptides.Scientific reports · 2020Article
- Human Defensins: A Novel Approach in the Fight against Skin ColonizingAntibiotics (Basel, Switzerland) · 2020Review
- Review
- The Antimicrobial and Immunomodulatory Function of RNase 7 in Skin.Frontiers in immunology · 2019Review
- Staphylococcus aureus colonisation and its relationship with skin and soft tissue infection in New Zealand children.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- The Antimicrobial Peptide Human Beta-Defensin-3 Is Induced by Platelet-Released Growth Factors in Primary Keratinocytes.Mediators of inflammation · 2017Article
- Antimicrobial peptide exposure selects for Staphylococcus aureus resistance to human defence peptides.The Journal of antimicrobial chemotherapy · 2017Article
- Article
- Interleukin-17A (IL-17A) and IL-17F Are Critical for Antimicrobial Peptide Production and Clearance of Staphylococcus aureus Nasal Colonization.Infection and immunity · 2016Article
- Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa.Mucosal immunology · 2016Article
- RNase 7 in Cutaneous Defense.International journal of molecular sciences · 2016Review
- Foodborne disease outbreak in a resource-limited setting: a tale of missed opportunities and implications for response.The Pan African medical journal · 2016Article
- Selected Factors of Innate Immunity in Healthy Individuals with S. aureus Nasal Carriage.Frontiers in microbiology · 2016Article
- High throughput screening methods for assessing antibiofilm and immunomodulatory activities of synthetic peptides.Peptides · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent nasal carriage of Staphylococcus aureus is the primary reservoir for this pathogen and a risk factor for infection. The nares of 12 to 30% of healthy individuals are persistently colonized with staphylococci. Elucidating the yet enigmatic determinants of this phenomenon is of major public health interest. We hypothesized that differences in the levels of antimicrobial peptides (AMPs) that are found in human skin and have pronounced antistaphylococcal activity may contribute to this phenomenon. We compared constitutive and induced mRNA levels of RNase 7 and human β-defensin 3 (HBD-3) in healthy and experimentally wounded gluteal skin of 60 volunteers after ascertaining their carrier status through repeated nasal cultures. We found that levels of HBD-3 expression in skin of persistent nasal carriers of S. aureus were lower: induced levels in carriers were 63% (95% confidence interval, 43 to 94%; P = 0.02) and constitutive levels were 76% (95% confidence interval, 52 to 110%; P = 0.14) of those found in noncarriers. No such associations were present for RNase 7. In conjunction with existing knowledge, these findings suggest that healthy individuals with deficient HBD-3 expression in keratinocytes are more prone to persistent nasal colonization with S. aureus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.