Trial reportThe spine journal : official journal of the North American Spine Society2011
Immediate reduction in temporal sensory summation after thoracic spinal manipulation.
Trial report in The spine journal : official journal of the North American Spine Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hypoalgesic Effects of Specific vs Non-specific Cervical Manipulation in Healthy Subjects
Evaluating Specific and Non-Specific Mechanisms in Two Distinct Complementary/Integrative Interventions for Chronic Pain
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The regional effect of spinal manipulation on the pressure pain threshold in asymptomatic subjects: a systematic literature review.Chiropractic & manual therapies · 2018Pooled it
- Changes in pain sensitivity following spinal manipulation: a systematic review and meta-analysis.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2012Pooled it
- Trial
- Effects of chiropractic spinal manipulation on laser-evoked pain and brain activity.The journal of physiological sciences : JPS · 2021Trial
- Comparison of 2 Lumbar Manual Therapies on Temporal Summation of Pain in Healthy Volunteers.The journal of pain · 2017Trial
- Upper cervical and upper thoracic manipulation versus mobilization and exercise in patients with cervicogenic headache: a multi-center randomized clinical trial.BMC musculoskeletal disorders · 2016Trial
- The comparative effects of spinal and peripheral thrust manipulation and exercise on pain sensitivity and the relation to clinical outcome: a mechanistic trial using a shoulder pain model.The Journal of orthopaedic and sports physical therapy · 2015Trial
- Validation of a sham comparator for thoracic spinal manipulation in patients with shoulder pain.Manual therapy · 2015Trial
- Pain sensitivity subgroups in individuals with spine pain: potential relevance to short-term clinical outcome.Physical therapy · 2014Trial
- Spinal manipulative therapy-specific changes in pain sensitivity in individuals with low back pain (NCT01168999).The journal of pain · 2014Trial
- The Effect of Joint Mobilization and Manipulation on Proprioception: Systematic Review with Limited Meta-Analysis.Journal of functional morphology and kinesiology · 2026Review
- The efficacy of mechanical spinal manipulation in the standing position in patients with non-specific low back pain: a randomised placebo-controlled trial.Archives of medical science : AMS · 2026Article
- Therapeutic Soreness in Manual Therapy for Chronic Neck Pain: A Triphasic Model of Descending Pain Modulation.Journal of pain research · 2026Review
- The pathophysiologic mechanisms of spinal manipulative therapy in the management of chronic musculoskeletal pain.The Journal of the Canadian Chiropractic Association · 2025Article
- "The Dark Side of Musculoskeletal Care": Why Do Ineffective Techniques Seem to Work? A Comprehensive Review of Complementary and Alternative Therapies.Biomedicines · 2025Review
- Associations of Treatment Outcome Expectations and Pain Sensitivity after Cervical Spine Manipulation in Patients with Chronic Non-Specific Neck Pain: A Cohort Study.Healthcare (Basel, Switzerland) · 2024Article
- The effect of resistance exercise on multimodal pain thresholds in local and systemic muscle sites.Physiological reports · 2024Article
- Dry needling in the management of chronic tension-type headache associated with levator scapulae syndrome: A case report.Clinical case reports · 2024Article
- Acute Intermittent Hypoxia Did Not Alter Pain Sensitivity or Pain Intensity Ratings for Individuals with Chronic Low Back Pain: A Pilot Study.Journal of pain research · 2024Article
- Restoration of normal central pain processing following manual therapy in nonspecific chronic neck pain.PloS one · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
background contextSpinal manipulative techniques (SMT) have shown clinical effectiveness in some patients with musculoskeletal pain. PURPOSE: We performed the current experiment to test whether regional pain modulation is to be expected from thoracic SMT. STUDY DESIGN/
settingRandomized experimental design performed in a university pain laboratory. OUTCOME MEASURES: The primary outcome was experimental pain sensitivity in cervical and lumbar innervated area.
methodsNinety healthy volunteers were randomly assigned to receive one of three interventions (SMT, exercise, or rest) to the upper thoracic spine. Participants completed questionnaires about pain-related affect and expectations regarding each of the interventions. We collected experimental pain sensitivity measures of cervical and lumbar innervated areas before and immediately after randomly assigned intervention. Mixed model analysis of covariance was used to test changes in measures of experimental pain sensitivity.
resultsNo interactions or intervention (group) effects were noted for pressure or A-delta-mediated thermal pain responses. Participants receiving SMT had greater reductions in temporal sensory summation (TSS).
conclusionsThis present study indicates thoracic SMT that reduces TSS in healthy subjects. These findings extend our previous work in healthy and clinical subjects by indicating change in the nocioceptive afferent system occurred caudal to the region of SMT application. However, the duration of reduction in TSS is unknown, and more work needs to be completed in clinical populations to confirm the relevance of these findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.