ArticleMechanisms of ageing and development2011
Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits.
Article in Mechanisms of ageing and development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- The association between frailty and perceived physical and mental fatigability: The Long Life Family Study.Journal of the American Geriatrics Society · 2024Article
- Frailty Index in the Colonias on the US-Mexico Border: A Special Report.Frontiers in medicine · 2021Article
- Composite Measure of Physiological Dysregulation as a Predictor of Mortality: The Long Life Family Study.Frontiers in public health · 2020Article
- Associations between a laboratory frailty index and adverse health outcomes across age and sex.Aging medicine (Milton (N.S.W)) · 2019Article
- Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Men Sustain Higher Dysregulation Levels Than Women Without Becoming Frail.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Late-life deficits in cognitive, physical and emotional functions, childhood intelligence and occupational profile: a life-course examination of the Aberdeen 1936 Birth Cohort (ABC1936).Age and ageing · 2016Article
- Childhood forecasting of a small segment of the population with large economic burden.Nature human behaviour · 2016Article
- Frailty prevalence and 10-year survival in community-dwelling older adults: results from the ESTHER cohort study.European journal of epidemiology · 2014Article
- Age-related deficit accumulation and the risk of late-life dementia.Alzheimer's research & therapy · 2014Article
- Association of healthy aging with parental longevity.Age (Dordrecht, Netherlands) · 2013Article
- Frailty in primary care: a review of its conceptualization and implications for practice.BMC medicine · 2012Review
- Quantitative measures of healthy aging and biological age.Healthy aging researchArticle
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 2 countries.
Funding
Abstract
We used an approach of cumulative deficits to evaluate the rate of aging in 4954 participants of the Long-Life Family Study (LLFS) recruited in the U.S. (Boston, New York, and Pittsburgh) and Denmark. We used an array of 85 health-related deficits covering major health dimensions including depression, cognition, morbidity, physical performance, and disability to construct several deficit indices (DIs) with overlapping and complementary sets of deficits to test robustness of the estimates. Our study shows that the DIs robustly characterize accelerated rates of aging irrespective of specific of deficits. When a wider spectrum of health dimensions is considered these rates are better approximated by quadratic law. Exponential rates are more characteristic for more severe health dimensions. The aging rates are the same for males and females. Individuals who contracted major diseases and those who were free of them exhibited the same aging rates as characterized by the DI constructed using mild deficits. Unlike health, disability can qualitatively alter the aging patterns of the LLFS participants. We report on systemic differences in health among the LLFS centenarians residing in New York and Boston. This study highlights importance of aggregated approaches to better understand systemic mechanisms of health deterioration in long-living individuals.
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