ArticleBiophysical journal2011
Cell protrusions and tethers: a unified approach.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A humanized βCell reports · 2022Article
- Quantitative interpretation of cell rolling velocity distribution.Biophysical journal · 2021Article
- Biomechanics of Neutrophil Tethers.Life (Basel, Switzerland) · 2021Review
- Cell membrane biophysics with optical tweezers.European biophysics journal : EBJ · 2018Review
- Incorporation of DDR2 clusters into collagen matrix via integrin-dependent posterior remnant tethering.International journal of biological sciences · 2018Article
- Effector and Regulatory T Cells Roll at High Shear Stress by Inducible Tether and Sling Formation.Cell reports · 2017Article
- Mapping cell surface adhesion by rotation tracking and adhesion footprinting.Scientific reports · 2017Article
- Microfluidics-based side view flow chamber reveals tether-to-sling transition in rolling neutrophils.Scientific reports · 2016Article
- Matrix confinement plays a pivotal role in regulating neutrophil-generated tractions, speed, and integrin utilization.The Journal of biological chemistry · 2015Article
- Yielding elastic tethers stabilize robust cell adhesion.PLoS computational biology · 2014Article
- Cytoskeleton modification and cholesterol depletion affect membrane properties and caveolae positioning of CHO cells.The Journal of membrane biology · 2014Article
- Lipid tubule growth by osmotic pressure.Journal of the Royal Society, Interface · 2013Article
- Neutrophil rolling at high shear: flattening, catch bond behavior, tethers and slings.Molecular immunology · 2013Review
- 'Slings' enable neutrophil rolling at high shear.Nature · 2012Article
- Molecular structure of membrane tethers.Biophysical journal · 2012Article
- Biomechanics of leukocyte rolling.Biorheology · 2011Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Low pulling forces applied locally to cell surface membranes produce viscoelastic cell surface protrusions. As the force increases, the membrane can locally separate from the cytoskeleton and a tether forms. Tethers can grow to great lengths exceeding the cell diameter. The protrusion-to-tether transition is known as the crossover. Here we propose a unified approach to protrusions and tethers providing, to our knowledge, new insights into their biomechanics. We derive a necessary and sufficient condition for a crossover to occur, a formula for predicting the crossover time, conditions for a tether to establish a dynamic equilibrium (characterized by constant nonzero pulling force and tether extension rate), a general formula for the tether material after crossover, and a general modeling method for tether pulling experiments. We introduce two general protrusion parameters, the spring constant and effective viscosity, valid before and after crossover. Their first estimates for neutrophils are 50 pN μm(-1) and 9 pN s μm(-1), respectively. The tether elongation after crossover is described as elongation of a viscoelastic-like material with a nonlinearly decaying spring (NLDs-viscoelastic material). Our model correctly describes the results of the published protrusion and tether pulling experiments, suggesting that it is universally applicable to such experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.