ArticleTheoretical biology & medical modelling2011
Module-based multiscale simulation of angiogenesis in skeletal muscle.
Article in Theoretical biology & medical modelling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Human Dermal Microvascular Arterial and Venous Blood Endothelial Cells and Their Use in Bioengineered Dermo-Epidermal Skin Substitutes.Small methods · 2025Article
- Computer model coupling hemodynamics and oxygen transport in the coronary capillary network: Pulsatile vs. non-pulsatile analysis.Computer methods and programs in biomedicine · 2025Article
- Angiogenic Microvascular Wall Shear Stress Patterns Revealed Through Three-dimensional Red Blood Cell Resolved Modeling.Function (Oxford, England) · 2023Article
- Computational models for generating microvascular structures: Investigations beyond medical imaging resolution.WIREs mechanisms of disease · 2023Review
- Systems biology of angiogenesis signaling: Computational models and omics.WIREs mechanisms of disease · 2022Review
- Dynamic Multiscale Regulation of Perfusion Recovery in Experimental Peripheral Arterial Disease: A Mechanistic Computational Model.JACC. Basic to translational science · 2022Article
- Modeling acute and chronic vascular responses to a major arterial occlusion.Microcirculation (New York, N.Y. : 1994) · 2021Article
- Simulation of angiogenesis in three dimensions: Application to cerebral cortex.PLoS computational biology · 2021Article
- Sex differences in cancer mechanisms.Biology of sex differences · 2020Review
- Agent-based modeling of morphogenetic systems: Advantages and challenges.PLoS computational biology · 2019Review
- The importance of geometry in the corneal micropocket angiogenesis assay.PLoS computational biology · 2018Article
- Agent-based modeling of the interaction between CD8+ T cells and Beta cells in type 1 diabetes.PloS one · 2018Article
- Advanced computational workflow for the multi-scale modeling of the bone metabolic processes.Medical & biological engineering & computing · 2017Review
- Microvessel Chaste: An Open Library for Spatial Modeling of Vascularized Tissues.Biophysical journal · 2017Article
- Image-based modelling of skeletal muscle oxygenation.Journal of the Royal Society, Interface · 2017Review
- Effects of endothelial cell proliferation and migration rates in a computational model of sprouting angiogenesis.Scientific reports · 2016Article
- An imaging-based computational model for simulating angiogenesis and tumour oxygenation dynamics.Physics in medicine and biology · 2016Article
- Cells as strain-cued automata.Journal of the mechanics and physics of solids · 2016Article
- Systems biology of the microvasculature.Integrative biology : quantitative biosciences from nano to macro · 2015Review
- Divide and conquer, faster: speeding up molecular simulations.Biophysical journal · 2015Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundMathematical modeling of angiogenesis has been gaining momentum as a means to shed new light on the biological complexity underlying blood vessel growth. A variety of computational models have been developed, each focusing on different aspects of the angiogenesis process and occurring at different biological scales, ranging from the molecular to the tissue levels. Integration of models at different scales is a challenging and currently unsolved problem.
resultsWe present an object-oriented module-based computational integration strategy to build a multiscale model of angiogenesis that links currently available models. As an example case, we use this approach to integrate modules representing microvascular blood flow, oxygen transport, vascular endothelial growth factor transport and endothelial cell behavior (sensing, migration and proliferation). Modeling methodologies in these modules include algebraic equations, partial differential equations and agent-based models with complex logical rules. We apply this integrated model to simulate exercise-induced angiogenesis in skeletal muscle. The simulation results compare capillary growth patterns between different exercise conditions for a single bout of exercise. Results demonstrate how the computational infrastructure can effectively integrate multiple modules by coordinating their connectivity and data exchange. Model parameterization offers simulation flexibility and a platform for performing sensitivity analysis.
conclusionsThis systems biology strategy can be applied to larger scale integration of computational models of angiogenesis in skeletal muscle, or other complex processes in other tissues under physiological and pathological conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.