ArticleAlcoholism, clinical and experimental research2011
A longitudinal twin study of effects of adolescent alcohol abuse on the neurophysiology of attention and orienting.
Article in Alcoholism, clinical and experimental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.Journal of psychopathology and clinical science · 2024Pooled it
- Association of lifetime major depressive disorder with enhanced attentional sensitivity measured with P3 response in young adult twins.Biological psychology · 2022Article
- Alcohol Consumption during Adolescence in a Mouse Model of Binge Drinking Alters the Intrinsic Excitability and Function of the Prefrontal Cortex through a Reduction in the Hyperpolarization-Activated Cation Current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Early maturation and substance use across adolescence and young adulthood: A longitudinal study of Finnish twins.Development and psychopathology · 2018Article
- Adult rat cortical thickness changes across age and following adolescent intermittent ethanol treatment.Addiction biology · 2017Article
- Diffusion tensor imaging reveals adolescent binge ethanol-induced brain structural integrity alterations in adult rats that correlate with behavioral dysfunction.Addiction biology · 2016Article
- Adolescent intermittent ethanol exposure enhances ethanol activation of the nucleus accumbens while blunting the prefrontal cortex responses in adult rat.Neuroscience · 2015Article
- Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study.Psychophysiology · 2014Article
- Associations between sexual abstinence ideals, religiosity, and alcohol abstinence: a longitudinal study of Finnish twins.Journal of sex research · 2014Article
- Understanding alcohol use disorders with neuroelectrophysiology.Handbook of clinical neurology · 2014Review
- The Finnish Twin Cohort Study: an update.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2013Review
- Neurotoxic effects of alcohol in adolescence.Annual review of clinical psychology · 2013Review
- Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function.Frontiers in psychiatry · 2013Article
- Cognitive training for impaired neural systems in neuropsychiatric illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Review
- Neuropsychological dysfunctions among chronic schizophrenia patients, alcohol dependence cases, and normal subjects: A comparative study.Industrial psychiatry journalArticle
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Abstract
backgroundLong-term functional brain effects of adolescent alcohol abuse remain uncertain, partially because of difficulties in distinguishing inherited deficits from neuronal effects of ethanol and by confounds associated with alcohol abuse, especially nicotine exposure. We conducted a longitudinal twin study to determine neurocognitive effects of adolescent alcohol abuse, as measured with the auditory event-related potential (ERP) component P3, a putative marker of genetic vulnerability to alcoholism.
methodsTwin pairs (N=177; 150 selected for intrapair concordance/discordance for alcohol-related problems at age 18½) were recruited from ongoing studies of twins born 1975-1979 in Finland. Alcohol and tobacco use were assessed with questionnaires at ages 16, 17, 18½, and ~25, and by a structured psychiatric interview concurrent with the ERP testing at mean age 25.8. During ERP recordings, subjects were instructed to detect target tones within a train of frequent "standards" and to ignore occasional "novel" sounds. To distinguish familial factors from ethanol effects, ERP and self-reported alcohol use measures were incorporated into hierarchical multiple regression (HMR) analysis, and intrapair differences in ERP were associated with intra-pair differences in alcohol variables.
resultsNovel-sound P3 amplitude correlated negatively with self-reported alcohol use in both between- and within-family analyses. No similar effect was observed for target-tone P3. HMR results suggest that twins' similarity for novel-sound P3 amplitude is modulated by their alcohol use, and this effect of alcohol use is influenced by genetic factors.
conclusionsOur results, from a large sample of twins selected from a population-based registry for pairwise concordance/discordance for alcohol problems at 18½, demonstrate that adolescent alcohol abuse is associated with subtle neurophysiological changes in attention and orienting. The changes are reflected in decreased novel-sound P3 amplitude and may be modified by genetic factors.
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