ArticleActa orthopaedica2011
The effect of both a thoracic trauma and a soft-tissue trauma on fracture healing in a rat model.
Article in Acta orthopaedica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Polytrauma impairs fracture healing accompanied by increased persistence of innate inflammatory stimuli and reduced adaptive response.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Review
- Influence of Thoracic Trauma on Fracture Healing in Long Bones-A Retrospective Analysis.Journal of clinical medicine · 2022Article
- Fracture fixation strategy and specific muscle tissue availability of neutrophilic granulocytes following mono- and polytrauma: intramedullary nailing vs. external fixation of femoral fractures.European journal of medical research · 2020Article
- Intact Glucocorticoid Receptor Dimerization Is Deleterious in Trauma-Induced Impaired Fracture Healing.Frontiers in immunology · 2020Article
- Traumatic injury pattern is of equal relevance as injury severity for experimental (poly)trauma modeling.Scientific reports · 2019Article
- Burn and thoracic trauma alters fracture healing, systemic inflammation, and leukocyte kinetics in a rat model of polytrauma.Journal of orthopaedic surgery and research · 2019Article
- An increase in myeloid cells after severe injury is associated with normal fracture healing: a retrospective study of 62 patients with a femoral fracture.Acta orthopaedica · 2018Article
- Severe Burn-Induced Inflammation and Remodeling of Achilles Tendon in a Rat Model.Shock (Augusta, Ga.) · 2018Article
- Fracture healing: mechanisms and interventions.Nature reviews. Rheumatology · 2015Review
- Delayed bone regeneration is linked to chronic inflammation in murine muscular dystrophy.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Chronic calcaneal osteomyelitis associated with soft-tissue defect could be successfully treated with platelet-rich plasma: a case report.International wound journal · 2013Article
- Special Review: Accelerating fracture repair in humans: a reading of old experiments and recent clinical trials.BoneKEy reports · 2013Review
- Unraveling macrophage contributions to bone repair.BoneKEy reports · 2013Review
- Article
- Fracture healing under healthy and inflammatory conditions.Nature reviews. Rheumatology · 2012Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThere is some clinical evidence that fracture healing is impaired in multiply injured patients. Nothing is known, however, about the effects of various types of injuries and their contribution to a possible disturbance of the fracture-healing process. We investigated the effect of a thoracic trauma and an additional soft-tissue trauma on fracture healing in a rat tibia model.
methods3 groups of rats were operated: group A with a simple fracture of the tibia and fibula, group B with a fracture and an additional thoracic trauma, and group C with a fracture, thoracic trauma, and an additional soft-tissue trauma. The fracture and the soft-tissue injury were produced by a special guillotine-like device and the thoracic trauma by a blast wave generator. After one day, the serum level of IL-6 was quantified, and at the end of the study (28 days) the mechanical properties and the callus volume of the healed tibia were determined.
resultsIncreasing the severity of the injury caused IL-6 levels to more than double 1 day after injury. It halved the load to failure in mechanical tests and led to reduced callus volume after 28 days of healing.
interpretationFracture healing is impaired when additional thoracic trauma and soft tissue trauma occurs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.