Trial reportThe New England journal of medicine2011
Myocardial viability and survival in ischemic left ventricular dysfunction.
Trial report in The New England journal of medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 229 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Surgical Treatment for Ischemic Heart Failure (STICH)
Sequential Treatment of Extra-Corporeal Shock Wave Combined With aUtologous Bone marRow Mesenchymal Stem Cells in Patients With ischEmic Heart Disease : the S-CURE Study
Who cites it
229 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Update of the Brazilian Guideline on Nuclear Cardiology - 2020.Arquivos brasileiros de cardiologia · 2020Guideline
- Left ventricular contractile reserve by stress echocardiography as a predictor of response to cardiac resynchronization therapy in heart failure: a systematic review and meta-analysis.BMC cardiovascular disorders · 2017Pooled it
- Outcome Reporting in Cardiac Surgery Trials: Systematic Review and Critical Appraisal.Journal of the American Heart Association · 2015Pooled it
- 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. Developed in collaboration with the American College of Surgeons, American Society of Anesthesiologists, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Anesthesiologists, and Society of Vascular Medicine Endorsed by the Society of Hospital Medicine.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Guideline
- Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy.The New England journal of medicine · 2019Trial
- Burden of medical co-morbidities and benefit from surgical revascularization in patients with ischaemic cardiomyopathy.European journal of heart failure · 2019Trial
- Intra-procedural determination of viability by myocardial deformation imaging: a randomized prospective study in the cardiac catheter laboratory.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Trial
- Two-Year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation.The New England journal of medicine · 2016Trial
- Importance of angina in patients with coronary disease, heart failure, and left ventricular systolic dysfunction: insights from STICH.Journal of the American College of Cardiology · 2015Trial
- Severity of Remodeling, Myocardial Viability, and Survival in Ischemic LV Dysfunction After Surgical Revascularization.JACC. Cardiovascular imaging · 2015Trial
- Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary artery bypass surgery: results of the Surgical Treatment for Ischemic Heart Failure trial.The Journal of thoracic and cardiovascular surgery · 2014Trial
- Extent of coronary and myocardial disease and benefit from surgical revascularization in ischemic LV dysfunction [Corrected].Journal of the American College of Cardiology · 2014Trial
- Trial
- The STICH trial (Surgical Treatment for Ischemic Heart Failure): mode-of-death results.JACC. Heart failure · 2013Trial
- Trial
- Inducible myocardial ischemia and outcomes in patients with coronary artery disease and left ventricular dysfunction.Journal of the American College of Cardiology · 2013Trial
- The predictive value ofThe international journal of cardiovascular imaging · 2026Article
- Invasive and medical management approaches to non-acute myocardial ischaemic syndromes.Nature reviews. Cardiology · 2026Review
- Optimizing protected PCI strategies in the setting of chronic kidney disease and advanced coronary artery disease: a clinical case-based discussion.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Optimal surgical management of patients with severely reduced left ventricular ejection fraction undergoing coronary artery bypass grafting.Heart and vessels · 2026Article
169 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
backgroundThe assessment of myocardial viability has been used to identify patients with coronary artery disease and left ventricular dysfunction in whom coronary-artery bypass grafting (CABG) will provide a survival benefit. However, the efficacy of this approach is uncertain.
methodsIn a substudy of patients with coronary artery disease and left ventricular dysfunction who were enrolled in a randomized trial of medical therapy with or without CABG, we used single-photon-emission computed tomography (SPECT), dobutamine echocardiography, or both to assess myocardial viability on the basis of prespecified thresholds.
resultsAmong the 1212 patients enrolled in the randomized trial, 601 underwent assessment of myocardial viability. Of these patients, we randomly assigned 298 to receive medical therapy plus CABG and 303 to receive medical therapy alone. A total of 178 of 487 patients with viable myocardium (37%) and 58 of 114 patients without viable myocardium (51%) died (hazard ratio for death among patients with viable myocardium, 0.64; 95% confidence interval [CI], 0.48 to 0.86; P=0.003). However, after adjustment for other baseline variables, this association with mortality was not significant (P=0.21). There was no significant interaction between viability status and treatment assignment with respect to mortality (P=0.53).
conclusionsThe presence of viable myocardium was associated with a greater likelihood of survival in patients with coronary artery disease and left ventricular dysfunction, but this relationship was not significant after adjustment for other baseline variables. The assessment of myocardial viability did not identify patients with a differential survival benefit from CABG, as compared with medical therapy alone. (Funded by the National Heart, Lung, and Blood Institute; STICH ClinicalTrials.gov number, NCT00023595.).
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.