ArticleBehavioral neuroscience2011
Clozapine and PD149163 elevate prepulse inhibition in Brown Norway rats.
Article in Behavioral neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Oxytocin improves probabilistic reversal learning but not effortful motivation in Brown Norway rats.Neuropharmacology · 2019Article
- A Review of Oxytocin's Effects on the Positive, Negative, and Cognitive Domains of Schizophrenia.Biological psychiatry · 2016Review
- Repeated effects of the neurotensin receptor agonist PD149163 in three animal tests of antipsychotic activity: assessing for tolerance and cross-tolerance to clozapine.Pharmacology, biochemistry, and behavior · 2015Article
- A Role for Oxytocin in the Etiology and Treatment of Schizophrenia.Frontiers in endocrinology · 2015Review
- Systemic administration of the neurotensin NTS₁-receptor agonist PD149163 improves performance on a memory task in naturally deficient male brown Norway rats.Experimental and clinical psychopharmacology · 2014Article
- Effects of the neurotensin NTS₁ receptor agonist PD149163 on visual signal detection in rats.European journal of pharmacology · 2013Article
- Different interactions of prolyl oligopeptidase and neurotensin in dopaminergic function of the rat nigrostriatal and mesolimbic pathways.Neurochemical research · 2012Article
- Oxytocin in schizophrenia: a review of evidence for its therapeutic effects.Acta neuropsychiatrica · 2012Article
- The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor gating.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2012Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Unmedicated schizophrenia patients exhibit deficits in prepulse inhibition (PPI) of the acoustic startle response. Similar deficits can be induced in rodents via a variety of manipulations and these deficits can be reversed by antipsychotics. Brown Norway (BN) rats exhibit natural PPI deficits under certain parametric conditions. We treated BN rats with haloperidol or clozapine to determine if the BN rat is a useful animal model with predictive validity for the effects of antipsychotics. In addition, we also tested PD149163, a neurotensin-1 receptor agonist, which has been shown to exhibit antipsychotic-like effects in several other animal models. BN rats received subcutaneous injections of either saline or one of two doses of haloperidol (0.5 mg/kg, 1.0 mg/kg), clozapine (7.5 mg/kg, 10 mg/kg) or PD149163 (1.0 mg/kg, 2.0 mg/kg). PPI was measured in startle chambers 30 min after injection. Systemic clozapine and PD149163 but not haloperidol facilitated PPI in BN rats (p < .001). This drug response profile suggests that the BN rat may be useful for detecting atypical antipsychotics and antipsychotics with novel mechanisms of action. The results also add to the evidence suggesting that PD149163 may have antipsychotic properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.