ArticleBehavioral neuroscience2011
Nucleus accumbens dopamine modulates response rate but not response timing in an interval timing task.
Article in Behavioral neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Dopamine Dynamics in the Nucleus Accumbens Reflect Confidence in Detecting the Occurrence and Nonoccurrence of Visual Signals in Perceptual Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Communication between the medial frontal cortex and mediodorsal thalamus is required for timing performance in rats.Neurobiology of learning and memory · 2026Article
- An auditory cortical-striatal circuit supports sound-triggered timing to predict future events.PLoS biology · 2025Article
- A Cortico-Striatal Circuit for Sound-Triggered Prediction of Reward Timing.bioRxiv : the preprint server for biology · 2023Article
- Striatal dopamine D1 receptors control motivation to respond, but not interval timing, during the timing task.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Effects of nucleus accumbens amphetamine administration on performance in a delay discounting task.Behavioural brain research · 2017Article
- Interval timing, temporal averaging, and cue integration.Current opinion in behavioral sciences · 2016Article
- Corticostriatal Field Potentials Are Modulated at Delta and Theta Frequencies during Interval-Timing Task in Rodents.Frontiers in psychology · 2016Article
- Reinforcement probability modulates temporal memory selection and integration processes.Acta psychologica · 2014Article
- Endocannabinoid-dependent modulation of phasic dopamine signaling encodes external and internal reward-predictive cues.Frontiers in psychiatry · 2014Review
- Dissociations between interval timing and intertemporal choice following administration of fluoxetine, cocaine, or methamphetamine.Behavioural processes · 2014Article
- Executive dysfunction in Parkinson's disease and timing deficits.Frontiers in integrative neuroscience · 2013Review
- Hippocampus, time, and memory--a retrospective analysis.Behavioral neuroscience · 2013Article
- Prefrontal cortical-striatal dopamine receptor mRNA expression predicts distinct forms of impulsivity.The European journal of neuroscience · 2013Article
- Prefrontal D1 dopamine signaling is required for temporal control.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Acquisition of "Start" and "Stop" response thresholds in peak-interval timing is differentially sensitive to protein synthesis inhibition in the dorsal and ventral striatum.Frontiers in integrative neuroscience · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
While previous work has demonstrated that systemic dopamine manipulations can modulate temporal perception by altering the speed of internal clock processes, the neural site of this modulation remains unclear. Based on recent research suggesting that changes in incentive salience can alter the perception of time, as well as work showing that nucleus accumbens (NAc) shell dopamine (DA) levels modulate the incentive salience of discriminative stimuli that predict instrumental outcomes, we assessed whether microinjections of DA agents into the NAc shell would impact temporal perception. Rats were trained on either a 10-s or 30-s temporal production procedure and received intra-NAc shell microinfusions of sulpiride, amphetamine, and saline. Results showed that NAc DA modulations had no effect on response timing, but intra-NAc shell sulpiride microinfusions significantly decreased response rates relative to saline and amphetamine. Our findings therefore suggest that neither NAc shell DA levels, nor the resultant changes in incentive salience signaled by this structure, impact temporal control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.