Evidence map›Paper›PMID 21462356›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

Microfabrication and nanotechnology in stent design.

Adam W Martinez, Elliot L Chaikof

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 98 citations in OpenAlex.

  1. Review
  2. Review
  3. Two-Staged Technology for CoCr Stent Production by SLM.Materials (Basel, Switzerland) · 2024
    Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Bioresorbable Polymeric Scaffold in Cardiovascular Applications.International journal of molecular sciences · 2020
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Adam W MartinezDepartment of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.
Elliot L Chaikof
Emory University · USGeorgia Institute of Technology · US

Funding

MEMBRANE-MIMETIC ASSEMBLIES FOR ENDOTHELIAL MIGRATIONR01HL056819 · NHLBI · EMORY UNIVERSITY · PI CHAIKOF, ELLIOT · 1998 to 2016
$5.2M
A Bioinspired Small Diameter Vascular ConduitR01HL083867 · NHLBI · EMORY UNIVERSITY · PI CHAIKOF, ELLIOT · 2006 to 2010
$3.8M
NHLBI NIH HHS R01 HL056819NHLBI NIH HHS R01 HL083867
6 · The paper itself

Abstract

Intravascular stents were first introduced in the 1980s as an adjunct to primary angioplasty for management of early complications, including arterial dissection, or treatment of an inadequate technical outcome due to early elastic recoil of the atherosclerotic lesion. Despite the beneficial effects of stenting, persistent high rates of restenosis motivated the design of drug-eluting stents for delivery of agents to limit the proliferative and other inflammatory responses within the vascular wall that contribute to the development of a restenotic lesion. These strategies have yielded a significant reduction in the incidence of restenosis, but challenges remain, including incomplete repair of the endothelium at the site of vascular wall injury that may be associated with a late risk of thrombosis. A failure of vessel wall healing has been attributed primarily to the use of polymeric stent coatings, but the effects of the eluted drug and other material properties or design features of the stent cannot be excluded. Improvements in stent microfabrication, as well as the introduction of alternative materials may help to address those limitations that inhibit stent performance. This review describes the application of novel microfabrication processes and the evolution of new nanotechnologies that hold significant promise in eliminating existing shortcomings of current stent platforms.

Indexed as

Prosthesis DesignStentsAnimalsBiopharmaceuticsMicrotechnologyNanotechnologySurface Properties

Identifiers

PMID21462356
PMCPMC3480085
OpenAlexW2006666821

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.