ArticleJournal of experimental zoology. Part B, Molecular and developmental evolution2011
Evolution of pleiotropy: epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map.
Article in Journal of experimental zoology. Part B, Molecular and developmental evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Quantitative trait loci, G×E and G×G for glycemic traits: response to metformin and placebo in the Diabetes Prevention Program (DPP).Journal of human genetics · 2022Trial
- Article
- Epistasis and pleiotropy-induced variation for plant breeding.Plant biotechnology journal · 2024Review
- Pleiotropy, epistasis and the genetic architecture of quantitative traits.Nature reviews. Genetics · 2024Review
- [Evolutionary cardiology and experimental research].Archivos de cardiologia de Mexico · 2022Article
- The complex role of genetic background in shaping the effects of spontaneous and induced mutations.Yeast (Chichester, England) · 2021Review
- CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications.Frontiers in immunology · 2021Article
- Evolution of Epistatic Networks and the Genetic Basis of Innate Behaviors.Trends in genetics : TIG · 2020Review
- Why does allometry evolve so slowly?Integrative and comparative biology · 2019Article
- Plastic responses to novel environments are biased towards phenotype dimensions with high additive genetic variation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels.Alzheimer's research & therapy · 2018Article
- Epistasis and Pleiotropy Affect the Modularity of the Genotype-Phenotype Map of Cross-Resistance in HIV-1.Molecular biology and evolution · 2016Article
- Directional selection effects on patterns of phenotypic (co)variation in wild populations.Proceedings. Biological sciences · 2016Article
- Modularity: genes, development and evolution.Annual review of ecology, evolution, and systematics · 2016Article
- Complex constraints on allometry revealed by artificial selection on the wing of Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Integrated phenotypes: understanding trait covariation in plants and animals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- A versatile omnibus test for detecting mean and variance heterogeneity.Genetic epidemiology · 2014Article
- APOE modulates the correlation between triglycerides, cholesterol, and CHD through pleiotropy, and gene-by-gene interactions.Genetics · 2013Article
- Genomic correlates of relationship QTL involved in fore- versus hind limb divergence in mice.Genome biology and evolution · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The genotype-phenotype (GP) map consists of developmental and physiological mechanisms mapping genetic onto phenotypic variation. It determines the distribution of heritable phenotypic variance on which selection can act. Comparative studies of morphology as well as of gene regulatory networks show that the GP map itself evolves, yet little is known about the actual evolutionary mechanisms involved. The study of such mechanisms requires exploring the variation in GP maps at the population level, which presently is easier to quantify by statistical genetic methods rather than by regulatory network structures. We focus on the evolution of pleiotropy, a major structural aspect of the GP map. Pleiotropic genes affect multiple traits and underlie genetic covariance between traits, often causing evolutionary constraints. Previous quantitative genetic studies have demonstrated population-level variation in pleiotropy in the form of loci, at which genotypes differ in the genetic covariation between traits. This variation can potentially fuel evolution of the GP map under selection and/or drift. Here, we propose a developmental mechanism underlying population genetic variation in covariance and test its predictions. Specifically, the mechanism predicts that the loci identified as responsible for genetic variation in pleiotropy are involved in trait-specific epistatic interactions. We test this prediction for loci affecting allometric relationships between traits in an advanced intercross between inbred mouse strains. The results consistently support the prediction. We further find a high degree of sign epistasis in these interactions, which we interpret as an indication of adaptive gene complexes within the diverged parental lines.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.