Evidence map›Paper›PMID 21461992›Full record

ReviewSeminars in immunopathology2011

Immunotherapy with pluripotent stem cell-derived dendritic cells.

Satoru Senju, Yusuke Matsunaga, Satoshi Fukushima, Shinya Hirata, Yutaka Motomura, Daiki Fukuma, Hidetake Matsuyoshi, Yasuharu Nishimura

Abstract readReview
PubMed Publisher
In one paragraph

Review in Seminars in immunopathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Satoru SenjuDepartment of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. senjusat@gpo.kumamoto-u.ac.jp
Yusuke Matsunaga
Satoshi Fukushima
Shinya Hirata
Yutaka Motomura
Daiki Fukuma
Hidetake Matsuyoshi
Yasuharu Nishimura

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vivo transfer of dendritic cells (DC) has proven efficient in the priming of T cells and is regarded as a powerful means of providing anti-cancer immunotherapy. Clinical trials of anti-cancer therapy with DC pulsed with peptide antigens have been carried out in many institutions, although dramatic therapeutic effect has not been observed in most of the trials. Negative regulation of the immune response by DC might be applicable to treatment of autoimmune diseases and transplantation medicine. Currently, the DC used for anti-cancer vaccine therapy are generated from the peripheral blood monocytes of the patients. However, there is a limitation in the number of available monocytes and the potential of monocytes to differentiate into DC varies depending on the individual blood donors. To resolve the issue of the cell source for DC therapy, several groups have developed methods to generate DC from pluripotent stem cells. This review introduces methods to generate functional DC from pluripotent stem cells of mouse and human.

Indexed as

AnimalsAutoimmunityCell DifferentiationDendritic CellsEmbryonic Stem CellsHumansImmunomodulationImmunosuppression TherapyInduced Pluripotent Stem CellsMicePluripotent Stem CellsT-Lymphocytes, Cytotoxic

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.