ArticleArchives of virology2011
Detection of human rhinoviruses in the lower respiratory tract of lung transplant recipients.
Article in Archives of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Rapid molecular detection of airway pathogens in lung transplant recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2021Observational
- Article
- Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections.Frontiers in immunology · 2020Review
- Natural Killer Cells and Host Defense Against Human Rhinoviruses Is Partially Dependent on Type I IFN Signaling.Frontiers in cellular and infection microbiology · 2020Article
- Use of an innovative and non-invasive device for virologic sampling of cough aerosols in patients with community and hospital acquired pneumonia: a pilot study.Journal of breath research · 2019Article
- Rhinovirus is associated with severe adult community-acquired pneumonia in China.Journal of thoracic disease · 2017Article
- Update in the treatment of non-influenza respiratory virus infection in solid organ transplant recipients.Expert opinion on pharmacotherapy · 2017Review
- Antiviral therapy for respiratory viral infections in immunocompromised patients.Expert review of anti-infective therapy · 2017Review
- Phylogenetic analysis of human rhinoviruses collected over four successive years in Sydney, Australia.Influenza and other respiratory viruses · 2016Article
- Therapeutic approach to respiratory infections in lung transplantation.Pulmonary pharmacology & therapeutics · 2015Article
- Human rhinovirus infections of the lower respiratory tract in hematopoietic stem cell transplant recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2013Article
- Lower respiratory tract viral infections in pediatric abdominal organ transplant recipients: a single hospital inpatient cohort study.Pediatric transplantation · 2013Article
- Human rhinoviruses.Clinical microbiology reviews · 2013Review
- Development of a quantitative real-time nucleic acid sequence-based amplification assay with an internal control using molecular beacon probes for selective and sensitive detection of human rhinovirus serotypes.Molecular biotechnology · 2012Article
- Clinical relevance of rhinovirus infections among adult hospitalized patients.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
- Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection.Clinical transplantationArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The occurrence of human rhinoviruses (HRV) and its relationship to clinical and histopathological findings were investigated in 127 bronchoalveolar lavage specimens from 36 lung transplant recipients by real-time RT-PCR. In addition, 286 samples from 235 other immunocompromised and immunocompetent patients were also studied. HRV was detected in 41.7% of lung transplant recipients vs 14.5% of other patients (p < 0.0001), and no differences in viral load were observed. Acute respiratory insufficiency was found in 15 cases, three of which were HRV positive (viral load, 6.3 x 10(6) RNA copies/ml in one patient with chronic graft dysfunction). A diagnosis of pneumonia was made in 10 out of 127 cases, two of which were HRV positive (viral load, 10(3)-10(4) in cases of co-infection). Acute rejection was diagnosed in 12 cases, three of which were HRV positive (viral load, 10(3) in two cases of co-infection and 10(5) in a single infection). HRV infection may involve the lower respiratory tract, particularly in the presence of an impaired pulmonary background, such as a transplanted lung. Clinical evaluation should take into account the viral load, with a load of >10(5) possibly being associated with clinical symptoms, although lower loads can be detected in both symptomatic and asymptomatic patients.
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