ArticleJournal of materials science. Materials in medicine2011
Preparation and characterization of self-assembled nanoparticles based on folic acid modified carboxymethyl chitosan.
Article in Journal of materials science. Materials in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 59 citations in OpenAlex.
- 5-Fluorouracil-Loaded Folic-Acid-Fabricated Chitosan Nanoparticles for Site-Targeted Drug Delivery Cargo.Polymers · 2022Article
- Biocompatibility Profile and In Vitro Cellular Uptake of Self-assembled Alginate Nanoparticles.Molecules (Basel, Switzerland) · 2019Article
- Synthesis of folate‑chitosan nanoparticles loaded with ligustrazine to target folate receptor positive cancer cells.Molecular medicine reports · 2017Article
- Novel amphiphilic folic acid-cholesterol-chitosan micelles for paclitaxel delivery.Oncotarget · 2017Article
- Possible role of nanocarriers in drug delivery against cervical cancer.Nano reviews & experiments · 2017Review
- Urokinase-coated chitosan nanoparticles for thrombolytic therapy: preparation and pharmacodynamics in vivo.Journal of thrombosis and thrombolysis · 2013Article
- Polysaccharide-based micelles for drug delivery.Pharmaceutics · 2013Article
- Preparation and characterization of nanoparticles based on histidine-hyaluronic acid conjugates as doxorubicin carriers.Journal of materials science. Materials in medicine · 2012Article
- Modeling and optimization of degree of folate grafted on chitosan and carboxymethyl-chitosan.Progress in biomaterialsArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Folate (FA) modified carboxymethyl chitosan (FCC) has been synthesized and the hydrogel nanoparticles can be prepared after the sonication. Formation and characteristics of nanoparticles of FCC were studied by fluorescence spectroscopy and dynamic light scattering methods. The critical aggregation concentration value of FCC in water was 9.34 × 10(-2) mg/ml and the mean hydrodynamic diameter of particle was 267.8 nm. The morphology of nanoparticles was observed by transmission electron microscopy which had spherical shape. Loading capacity (LC), loading efficiency (LE) and the in vitro release profiles of nanoparticles were investigated by doxorubicin (DOX) as a model drug. When the initially added amount of DOX versus the constant amount of FCC polymer was increased, the LC in the nanoparticles was gradually increased and the LE decreased. The in vitro release profile of the DOX from the FCC nanoparticles exhibited sustained release. Cellular uptake of FCC nanoparticles was found to be higher than that of nanoparticles based on linoleic acid (LA) modified carboxymethyl chitosan because of the FA-receptor-mediated endocytosis, thereby providing higher cytotoxicity against Hela cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.