Evidence map›Paper›PMID 21461918›Full record

ArticleJournal of materials science. Materials in medicine2011

Cell therapeutic options in liver diseases: cell types, medical devices and regulatory issues.

Andreas K Nussler, Katrin Zeilinger, Lilianna Schyschka, Sabrina Ehnert, Jörg C Gerlach, Xueying Yan, Serene M L Lee, Maren Ilowski, Wolfgang E Thasler, Thomas S Weiss

Abstract read
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Article in Journal of materials science. Materials in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andreas K NusslerDepartment of Traumatology, MRI, Klinikum rechts der Isar, Technische Universität München, Ismaningerstr. 22, 81675, Munich, Germany. andreas.nuessler@gmail.com
Katrin Zeilinger
Lilianna Schyschka
Sabrina Ehnert
Jörg C Gerlach
Xueying Yan
Serene M L Lee
Maren Ilowski
Wolfgang E Thasler
Thomas S Weiss

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although significant progress has been made in the field of orthotopic liver transplantation, cell-based therapies seem to be a promising alternative to whole-organ transplantation. The reasons are manifold but organ shortage is the main cause for this approach. However, many problems such as the question which cell type should be used or which application site is best for transplantation have been raised. In addition, some clinicians have had success by cultivating liver cells in bioreactors for temporary life support. Besides answering the question which cell type, which injection site or even which culture form should be used for liver support recent international harmonization of legal requirements is needed to be addressed by clinicians, scientists and companies dealing with cellular therapies. We here briefly summarize the possible cell types used to partially or temporarily correct liver diseases, the most recent development of bioreactor technology and important regulatory issues.

Indexed as

Liver, ArtificialBioreactorsCell Culture TechniquesChildChild, PreschoolEquipment DesignFemaleHepatocytesHumansInfantInformed ConsentLiverLiver DiseasesLiver FailureMaleMiddle Aged

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.