ArticleRheumatology international2012
Serum adenosine deaminase may predict disease activity in rheumatoid arthritis.
Article in Rheumatology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Serum adenosine deaminase activity is increased in systemic lupus erythematosus patients and correlated with disease activity.Immunologic research · 2018Trial
- The dynamic interplay of M1/M2-like macrophages and adenosine deaminase activity modulates COVID-19 severity.Open medicine (Warsaw, Poland) · 2026Article
- Quercetin mitigates rheumatoid arthritis by inhibiting adenosine deaminase in rats.Molecular medicine (Cambridge, Mass.) · 2022Article
- Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis.Drug design, development and therapy · 2022Review
- The association between serum adenosine deaminase levels and Graves' disease.Endocrine connections · 2021Article
- Adenosine deaminase modulates metabolic remodeling and orchestrates joint destruction in rheumatoid arthritis.Scientific reports · 2021Article
- Co-Nanoencapsulation of Vitamin DInflammation · 2019Article
- Salivary adiponectin, but not adenosine deaminase, correlates with clinical signs in women with Sjögren's syndrome: a pilot study.Clinical oral investigations · 2019Observational
- Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.Nature reviews. Rheumatology · 2016Review
- Serum Adenosine Deaminase as Inflammatory Marker in Rheumatoid Arthritis.Journal of clinical and diagnostic research : JCDR · 2015Article
- No association between serum adenosine deaminase activity and disease activity in Crohn's disease.Digestive diseases and sciences · 2015Article
- Serum Adenosine Deaminase Level is High But Not Related with Disease Activity Parameters in Patients with Rheumatoid Arthritis.The open rheumatology journal · 2014Article
- Purinergic signalling in the musculoskeletal system.Purinergic signalling · 2013Review
- Serum levels of calreticulin in correlation with disease activity in patients with rheumatoid arthritis.Journal of clinical immunology · 2013Article
- Serum anti-cyclic citrullinated peptide antibodies may predict disease activity in rheumatoid arthritis.Rheumatology international · 2012Article
- Serum adenosine deaminase in patients with rheumatoid arthritis treated with methotrexate.Journal of research in pharmacy practice · 2012Article
- A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release.Arthritis research & therapy · 2011Article
- Serum Adenosine Deaminase as a Useful Marker to Estimate Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine the relationship between serum adenosine deaminase (ADA) and disease activity, and to develop a new disease activity index based on serum ADA in rheumatoid arthritis (RA). Seventy RA patients were included. Disease activity based on Disease Activity Score 28-ESR (DAS28-ESR) and Disease Activity Score 28-CRP (DAS28-CRP) and serum ADA were measured. There were correlations when serum ADA compared with DAS28-ESR and DAS28-CRP. (R (2) = 0.014, 0.175, respectively, P values < 0.00). New disease activity index was developed by replacing ADA with ESR and CRP in DAS28-ESR and DAS28-CRP. There were strong correlations when new model compared with DAS28-ESR and DAS28-CRP. (R (2) = 0.94 and 0.95, respectively, P values < 0.00) The best new model values corresponding to DAS28-ESR values of 2.6, 3.2, and 5.1 were 2.79, 3.4, and 4.82, respectively; and new model values corresponding to DAS28-CRP values of 2.3, 2.7, and 4.1 were 2.1, 2.9, and 4, respectively. There were agreements when the new model compared with DAS28-ESR and DAS28-CRP for determination of patients in different disease activity categories. (Kappa = 0.81 and 0.71, respectively, P values < 0.00). The new disease activity index that applies serum ADA may help in predicting disease activity in RA.
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