ArticleJournal of mathematical biology2012
Mathematical modelling of stem cell differentiation: the PU.1-GATA-1 interaction.
Article in Journal of mathematical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Article
- Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling.Current stem cell reports · 2023Review
- Mean residence times of TF-TF and TF-miRNA toggle switches.Journal of biosciences · 2022Article
- A single-cell resolved cell-cell communication model explains lineage commitment in hematopoiesis.Development (Cambridge, England) · 2021Article
- A computational model of stem cell molecular mechanism to maintain tissue homeostasis.PloS one · 2020Article
- Intracellular Energy Variability Modulates Cellular Decision-Making Capacity.Scientific reports · 2019Article
- Reprogramming cooperative monotone dynamical systems.Proceedings of the ... IEEE Conference on Decision & Control. IEEE Conference on Decision & Control · 2018Article
- Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm.Nature communications · 2018Article
- Cell Fate Decision as High-Dimensional Critical State Transition.PLoS biology · 2016Article
- Mathematical modeling of GATA-switching for regulating the differentiation of hematopoietic stem cell.BMC systems biology · 2014Article
- Emodin can induce K562 cells to erythroid differentiation and improve the expression of globin genes.Molecular and cellular biochemistry · 2013Article
- Mapping differentiation under mixed culture conditions reveals a tunable continuum of T cell fates.PLoS biology · 2013Article
- Stochastic cytokine expression induces mixed T helper cell States.PLoS biology · 2013Article
- Population dynamics of normal and leukaemia stem cells in the haematopoietic stem cell niche show distinct regimes where leukaemia will be controlled.Journal of the Royal Society, Interface · 2013Article
- Article
- Stability and multiattractor dynamics of a toggle switch based on a two-stage model of stochastic gene expression.Biophysical journal · 2012Article
- A stochastic model of epigenetic dynamics in somatic cell reprogramming.Frontiers in physiology · 2012Article
- Reprogramming multistable monotone systems with application to cell fate control.IEEE transactions on network science and engineeringArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factors PU.1 and GATA-1 are known to be important in the development of blood progenitor cells. Specifically they are thought to regulate the differentiation of progenitor cells into the granulocyte/macrophage lineage and the erythrocyte/megakaryocite lineage. While several mathematical models have been proposed to investigate the interaction between the transcription factors in recent years, there is still debate about the nature of the progenitor state in the dynamical system, and whether the existing models adequately capture new knowledge about the interactions gleaned from experimental data. Further, the models utilise different formalisms to represent the genetic regulation, and it appears that the resulting dynamical system depends upon which formalism is adopted. In this paper we analyse the four existing models, and propose an alternative model which is shown to demonstrate a rich variety of dynamical systems behaviours found across the existing models, including both bistability and tristability required for modelling the undifferentiated progenitors.
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21461760What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.