ReviewJournal of neurology2011
Pharmacotherapy of vestibular and ocular motor disorders, including nystagmus.
Review in Journal of neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Secondary autoimmune immune ear disease (AIED): a systematic review and meta-analysis on vestibular manifestations of systemic autoimmune and inflammatory disorders.Clinical rheumatology · 2023Pooled it
- Pharmacovigilance study of drug-induced eye movement disorder based on FDA adverse event reports from 2004 to 2024.Scientific reports · 2025Article
- Increased 25-hydroxycholesterol as an indicator for patients with vestibular neuritis.Frontiers in neurology · 2025Article
- Nystagmus in Clinical Practice: From Diagnosis to Treatment-A Comprehensive Review.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- Voltage-gated calcium channels in genetic epilepsies.Journal of neurochemistry · 2024Review
- Consensus Paper: Latent Autoimmune Cerebellar Ataxia (LACA).Cerebellum (London, England) · 2024Article
- Clinical features andZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- A 6-month trial of memantine for nystagmus and associated phenomena in oculopalatal tremor.Frontiers in neurology · 2022Article
- Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease.Journal of clinical medicine · 2021Article
- Melatonin Exerts Anti-Inflammatory, Antioxidant, and Neuromodulatory Effects That Could Potentially Be Useful in the Treatment of Vertigo.International journal of otolaryngology · 2021Review
- Differential Proinflammatory Signature in Vestibular Migraine and Meniere Disease.Frontiers in immunology · 2019Article
- Therapy of episodic ataxias: case report and review of the literature.Drugs in context · 2019Review
- Aminopyridines and Acetyl-DL-leucine: New Therapies in Cerebellar Disorders.Current neuropharmacology · 2019Review
- European Position Statement on Diagnosis, and Treatment of Meniere's Disease.The journal of international advanced otology · 2018Review
- Eye Movement Research in the Twenty-First Century-a Window to the Brain, Mind, and More.Cerebellum (London, England) · 2018Article
- Predictive Capability of an iPad-Based Medical Device (meFrontiers in neurology · 2018Article
- Occulomotor Neural Integrator Dysfunction in Multiple Sclerosis: Insights From Neuroimaging.Frontiers in neurology · 2018Article
- Cerebellar disease associated with anti-glutamic acid decarboxylase antibodies: review.Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- Infantile nystagmus: an optometrist's perspective.Clinical optometry · 2017Review
- Comparison of linear motion perception thresholds in vestibular migraine and Menière's disease.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
We review current pharmacological treatments for peripheral and central vestibular disorders, and ocular motor disorders that impair vision, especially pathological nystagmus. The prerequisites for successful pharmacotherapy of vertigo, dizziness, and abnormal eye movements are the "4 D's": correct diagnosis, correct drug, appropriate dosage, and sufficient duration. There are seven groups of drugs (the "7 A's") that can be used: antiemetics; anti-inflammatory, anti-Ménière's, and anti-migrainous medications; anti-depressants, anti-convulsants, and aminopyridines. A recovery from acute vestibular neuritis can be promoted by treatment with oral corticosteroids. Betahistine may reduce the frequency of attacks of Ménière's disease. The aminopyridines constitute a novel treatment approach for downbeat and upbeat nystagmus, as well as episodic ataxia type 2 (EA 2); these drugs may restore normal "pacemaker" activity to the Purkinje cells that govern vestibular and cerebellar nuclei. A limited number of trials indicate that baclofen improves periodic alternating nystagmus, and that gabapentin and memantine improve acquired pendular and infantile (congenital) nystagmus. Preliminary reports suggest suppression of square-wave saccadic intrusions by memantine, and ocular flutter by beta-blockers. Thus, although progress has been made in the treatment of vestibular neuritis, some forms of pathological nystagmus, and EA 2, controlled, masked trials are still needed to evaluate treatments for many vestibular and ocular motor disorders, including betahistine for Ménière's disease, oxcarbazepine for vestibular paroxysmia, or metoprolol for vestibular migraine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.