ReviewEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2011
Changing paradigms in Whipple's disease and infection with Tropheryma whipplei.
Review in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Movement Disorders and Oculomotor Abnormalities in Whipple's Disease: An Updated Systematic Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Pooled it
- Whipple Disease: A Two-Decade Multisystem Masquerade Preceding Gastrointestinal Presentation.ACG case reports journal · 2026Article
- Deciphering whipple's disease complexity.Clinical and experimental medicine · 2026Review
- Article
- Tropheryma whipplei Infections, Mexico, 2019-2021.Emerging infectious diseases · 2025Article
- Gastroesophageal reflux disease increases the risk of rheumatoid arthritis: a bidirectional two-sample Mendelian randomization study.Scientific reports · 2024Article
- Whipple Disease Presenting as Isolated Transverse Myelitis with Permanent Neurological Damage in a Patient with Systemic Lupus Erythematosus: A Case Report of a Difficult Diagnosis with a Literature Review.Infectious disease reports · 2024Article
- Current knowledge of the immune reconstitution inflammatory syndrome in Whipple disease: a review.Frontiers in immunology · 2023Review
- Clinical Manifestations and Diagnosis of Axial Spondyloarthritis.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2021Review
- Hepatic and Extrahepatic Sources and Manifestations in Endoplasmic Reticulum Storage Diseases.International journal of molecular sciences · 2021Review
- Oral-Gut Microbiota and Arthritis: Is There an Evidence-Based Axis?Journal of clinical medicine · 2019Review
- Gut microbiota: a new angle for traditional herbal medicine research.RSC advances · 2019Review
- Epidemiology of Whipple's Disease in the USA Between 2012 and 2017: A Population-Based National Study.Digestive diseases and sciences · 2019Article
- Potential Role for Urine Polymerase Chain Reaction in the Diagnosis of Whipple's Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Whipple's Disease: Diagnostic Value of rpoB Gene PCR from Peripheral Blood Mononuclear Cells.Molecular diagnosis & therapy · 2018Article
- Gastrointestinal and Hepatic Disease in Rheumatoid Arthritis.Rheumatic diseases clinics of North America · 2018Review
- Clinical Manifestations, Treatment, and Diagnosis of Tropheryma whipplei Infections.Clinical microbiology reviews · 2017Review
- From focal sepsis to periodontal medicine: a century of exploring the role of the oral microbiome in systemic disease.The Journal of physiology · 2017Review
- Tropheryma whipplei as a Cause of Epidemic Fever, Senegal, 2010-2012.Emerging infectious diseases · 2016Article
- Deglycosylation of Tropheryma whipplei biofilm and discrepancies between diagnostic results during Whipple's disease progression.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More than a century after its first description through G.H. Whipple, the understanding of the chronic multisystemic infection called Whipple's disease is still limited. However, within recent years the knowledge about diagnosis and treatment, the pathogenesis, and the biology of the agent itself have been improved by molecular biological and immunological methods. Despite the ubiquitous presence of the causative bacterium Tropheryma whipplei, Whipple's disease is very rare, and immunogenetic host factors rather than the genotype of the agent influence the course of infection. Since the clinical features of classical Whipple's disease are non-specific and the spectrum of isolated organ-specific manifestations might be underestimated, diagnosis often still is a challenge. Moreover, besides classical Whipple's disease, there are newly recognized infections with T. whipplei, which do not fit in the concept of classical Whipple's disease, for example, acute self-limiting infection and isolated T. whipplei endocarditis. Antibiotic therapy is usually successful. However, several problems are still unresolved, of which the most important are the following: which antibiotic should be used; how long treatment should be continued; how the immunoreconstitution inflammatory syndrome, which may occur after initiation of treatment, should be managed; and which is the best treatment of severe neurological manifestations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.