ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2011
p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population.
Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- The association between the TP53 Arg72Pro polymorphism and colorectal cancer: An updated meta-analysis based on 32 studies.Oncotarget · 2017Pooled it
- Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas.International journal of epidemiology · 2016Pooled it
- An updated meta-analysis of the p53 codon 72 polymorphism and gastric cancer risk.Molecular biology reports · 2012Pooled it
- Article
- Impact of Interaction between Single Nucleotide Polymorphism of XRCC1, XRCC2, XRCC3 with Tumor Suppressor Tp53 Gene Increases Risk of Breast Cancer: A Hospital Based Case-Control Study.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- TP53 (rs1042522, rs28934571) and TP21 (rs1801270, rs1059234) Polymorphisms and Risk of Breast Cancer among Rural Women of Maharashtra: Findings from a Hospital Based Case- Control Study.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022Article
- Risk of Colorectal Carcinoma May Predispose to the Genetic Variants of theInternational journal of general medicine · 2021Article
- Five P53 SNPs Involved in Low Rectal Cancer Risk and Prognosis in a Chinese Population.Journal of Cancer · 2019Article
- Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis.Cancer management and research · 2018Article
- TP53 Polymorphisms and Colorectal Cancer Risk in Patients with Lynch Syndrome in Taiwan: A Retrospective Cohort Study.PloS one · 2016Article
- Polymorphisms of cell cycle regulator genesOncology letters · 2015Article
- TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development.World journal of gastroenterology · 2015Article
- Comparison of Genetic Variants in Cancer-Related Genes between Chinese Hui and Han Populations.PloS one · 2015Article
- Promoter polymorphisms of miR-34b/c are associated with risk of gastric cancer in a Chinese population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- TP53 alterations and colorectal cancer predisposition in south Indian population: a case-control study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Association between p53 codon 72 genetic polymorphisms and tobacco use and lung cancer risk in a Chinese population.Molecular biology reports · 2013Article
- Article
- Alterations of the TP53 gene in gastric and esophageal carcinogenesis.Journal of biomedicine & biotechnology · 2012Review
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe common p53 codon 72 polymorphism has been investigated as a risk factor for cancer in different populations; however, the results have been inconsistent. This study investigated the risk of developing gastric or colorectal cancer associated with the p53 codon 72 polymorphism in a Korean population.
methodsWe conducted a large-scale case-control study that included 2,213 gastric cancer patients; 1,829 colorectal cancer patients; and 1,700 healthy controls. Genotyping was performed with real-time polymerase chain reaction (PCR), using a TaqMan single-nucleotide polymorphism (SNP) genotyping assay.
resultsThe frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes of the p53 codon 72 polymorphism were 43.3, 42.0, and 13.0% in the gastric cancer patients; 40.5, 45.0, and 14.0% in the colorectal cancer patients; and 43.2, 45.6, and 11.2% in the controls, respectively. The Pro/Pro genotype was associated with an increased risk of gastric [age- and sex-adjusted odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.01-1.56, P = 0.04] and colorectal cancer (OR = 1.36, 95% CI = 1.07-1.72, P = 0.01). There were no significant interactions between the p53 codon 72 polymorphism and smoking or drinking.
conclusionsOur results suggest that the Pro/Pro genotype is associated with modest increases in the risks of gastric cancer and colorectal cancer in a Korean population.
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