ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2011
Links between hydrothermal environments, pyrophosphate, na(+), and early evolution.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 52 citations in OpenAlex.
- Nitazoxanide Analogs: Synthesis, In Vitro Giardicidal Activity, and Effects onInternational journal of molecular sciences · 2025Article
- Prebiotic Chemistry of Phosphite: Mild Thermal Routes to Form Condensed-P Energy Currency Molecules Leading Up to the Formation of Organophosphorus Compounds.Life (Basel, Switzerland) · 2023Article
- A prebiotic basis for ATP as the universal energy currency.PLoS biology · 2022Article
- Oxidative Phosphorus Chemistry Perturbed by Minerals.Life (Basel, Switzerland) · 2022Article
- Prebiotic Chemistry: The Role of Trimetaphosphate in Prebiotic Chemical Evolution.Frontiers in chemistry · 2022Review
- The Grayness of the Origin of Life.Life (Basel, Switzerland) · 2021Article
- Silicate-, Magnesium Ion-, and Urea-Induced Prebiotic Phosphorylation of Uridine via Pyrophosphate; Revisiting the Hot Drying Water Pool Scenario.Life (Basel, Switzerland) · 2020Article
- A new method to investigate the catalytic mechanism of YhdE pyrophosphatase by using a pyrophosphate fluorescence probe.Scientific reports · 2017Article
- On an early gene for membrane-integral inorganic pyrophosphatase in the genome of an apparently pre-luca extremophile, the archaeon Candidatus Korarchaeum cryptofilum.Journal of molecular evolution · 2014Article
- Glasses as sources of condensed phosphates on the early earth.Geochemical transactions · 2014Review
- Membrane Na+-pyrophosphatases can transport protons at low sodium concentrations.The Journal of biological chemistry · 2013Article
- Constant enthalpy change value during pyrophosphate hydrolysis within the physiological limits of NaCl.The Journal of biological chemistry · 2013Article
- Formation of activated biomolecules by condensation on mineral surfaces--a comparison of peptide bond formation and phosphate condensation.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2013Article
- Phosphate Activation via Reduced Oxidation State Phosphorus (P). Mild Routes to Condensed-P Energy Currency Molecules.Life (Basel, Switzerland) · 2013Article
- Pyrophosphate-fueled Na+ and H+ transport in prokaryotes.Microbiology and molecular biology reviews : MMBR · 2013Review
- Membrane-integral pyrophosphatase subfamily capable of translocating both Na+ and H+.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Isolation and characterization of a conserved domain in the eremophyte H+-PPase family.PloS one · 2013Article
- The significance of Mg in prebiotic geochemistry.Geobiology · 2012Article
- Article
- Na+-translocating membrane pyrophosphatases are widespread in the microbial world and evolutionarily precede H+-translocating pyrophosphatases.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The discovery that photosynthetic bacterial membrane-bound inorganic pyrophosphatase (PPase) catalyzed light-induced phosphorylation of orthophosphate (Pi) to pyrophosphate (PPi) and the capability of PPi to drive energy requiring dark reactions supported PPi as a possible early alternative to ATP. Like the proton-pumping ATPase, the corresponding membrane-bound PPase also is a H(+)-pump, and like the Na(+)-pumping ATPase, it can be a Na(+)-pump, both in archaeal and bacterial membranes. We suggest that PPi and Na(+) transport preceded ATP and H(+) transport in association with geochemistry of the Earth at the time of the origin and early evolution of life. Life may have started in connection with early plate tectonic processes coupled to alkaline hydrothermal activity. A hydrothermal environment in which Na(+) is abundant exists in sediment-starved subduction zones, like the Mariana forearc in the W Pacific Ocean. It is considered to mimic the Archean Earth. The forearc pore fluids have a pH up to 12.6, a Na(+)-concentration of 0.7 mol/kg seawater. PPi could have been formed during early subduction of oceanic lithosphere by dehydration of protonated orthophosphates. A key to PPi formation in these geological environments is a low local activity of water.
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