ArticleInternal and emergency medicine2013
Low frequency of cagA-positive Helicobacter pylori strains isolated from Iranian patients with MALT lymphoma.
Article in Internal and emergency medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- Helicobacter pylori cagA status and gastric mucosa-associated lymphoid tissue lymphoma: a systematic review and meta-analysis.Journal of health, population, and nutrition · 2022Pooled it
- Clinical relevance of the cagA, tnpA and tnpB genes in Helicobacter pylori.BMC gastroenterology · 2014Article
- High Prevalence of Helicobacter pylori hopQ II Genotype Isolated from Iranian Patients with Gastroduodenal Disorders.Journal of pathogens · 2014Article
- Novel Idea: Virulence-Based Therapy Against Helicobacter pylori Infection (Smart Therapy).Frontiers in medicine · 2014Review
- Prevalence of horB gene among the Helicobacter pylori strains isolated from dyspeptic patients: first report from Iran.Internal and emergency medicine · 2012Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori is predominantly involved in the etiology of digestive diseases. The aim of our study is to determine the relationship of cagA frequency with less investigated gastroduodenal disorders such as MALT (mucosal associated lymphoid tissue) lymphoma and gastric cancer. One hundred-twenty eight H. pylori-positive patients including: gastritis (n = 74), gastric cancer (n = 26) and MALT lymphoma (n = 28) were entered in our study. Antral biopsy specimen transport, bacterial culture and cagA detection were performed based on standard protocols. In brief, biopsies from positive H. pylori patients were investigated for presence of cagA gene by polymerase chain reactions (PCR) method. Of 128 consecutive Iranian patients with gastroduodenal disorders examined in our study, we identified 84 (65.6%) cagA-positive strains. However, six patients were excluded because of negative culture for identification of H. pylori. Prevalence of cagA in each categorized groups are following: 63/74 (85.1%) of gastritis patients, 16/28 (57.1%) and 5/26 gastric cancer (19.2%) of MALT lymphoma, respectively. Current findings reveal that the presence of cagA is not a reliable marker for prediction of digestive disorders caused by H. pylori infection. All our patients with gastric cancer were diagnosed as adenocarcinoma. The low rate of cagA among gastric cancer and MALT lymphoma groups was not statistically significant, possibly due to the small number of patients enrolled in the study. We suggest that a study with a high number of patients is needed for making more definitive assessment of the correlation between cagA-positive H. pylori and gastric cancer and MALT lymphoma.
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