ArticleBiochemistry research international2011
AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone.
Article in Biochemistry research international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- APEX1, a transcriptional hub for endochondral ossification and fracture repair.Bone research · 2026Article
- Differential Expression of c-fos Proto-Oncogene in Normal Oral Mucosa versus Squamous Cell CarcinomaAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease.The Journal of clinical investigation · 2016Article
- Curcumin inhibits cell proliferation and promotes apoptosis in human osteoclastoma cell through MMP-9, NF-κB and JNK signaling pathways.International journal of clinical and experimental pathology · 2015Article
- The PTH-Gαs-protein kinase A cascade controls αNAC localization to regulate bone mass.Molecular and cellular biology · 2014Article
- ANKRD1 acts as a transcriptional repressor of MMP13 via the AP-1 site.Molecular and cellular biology · 2014Article
- Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK.British journal of cancer · 2013Article
- Comparative characteristics of porous bioceramics for an osteogenic response in vitro and in vivo.PloS one · 2013Article
- PTHrP induces autocrine/paracrine proliferation of bone tumor cells through inhibition of apoptosis.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix-metalloproteinase-13 (MMP-13) has been shown to be an important protease in inflammatory and neoplastic conditions of the skeletal system. In particular, the stromal cells of giant cell tumor of bone (GCT) express very high levels of MMP-13 in response to the cytokine-rich environment of the tumor. We have previously shown that MMP-13 expression in these cells is regulated, at least in part, by the RUNX2 transcription factor. In the current study, we identify the expression of the c-Fos and c-Jun elements of the AP-1 transcription factor in these cells by protein screening assays and real-time PCR. We then used siRNA gene knockdown to determine that these elements, in particular c-Jun, are upstream regulators of MMP-13 expression and activity in GCT stromal cells. We conclude that there was no synergy found between RUNX2 and AP-1 in the regulation of the MMP13 expression and that these transcription factors may be independently regulated in these cells.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.