ArticleJournal of thyroid research2011
Clinical utility of serum interleukin-8 and interferon-alpha in thyroid diseases.
Article in Journal of thyroid research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Evaluation of the hematological parameters, inflammatory biomarkers, and thyroid hormones in hypothyroidism patients.BMC research notes · 2024Article
- Association of Pro-Inflammatory Cytokines with Vitamin D in Hashimoto's Thyroid Autoimmune Disease.Medicina (Kaunas, Lithuania) · 2023Article
- Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto's Thyroiditis.Journal of immunology research · 2023Article
- Article
- Interleukin-8, CXCL10, CXCL11 and their role in insulin resistance in adult females with subclinical hypothyroidism and prediabetes.Journal of clinical & translational endocrinology · 2022Article
- Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF-mutant papillary thyroid cancer to MAPK inhibitors.Nature communications · 2022Article
- Roles and new Insights of Macrophages in the Tumor Microenvironment of Thyroid Cancer.Frontiers in pharmacology · 2022Review
- Salivary biomarkers-assisted ultrasound-based differentiation of malignant and benign thyroid nodules.Gland surgery · 2022Article
- Thyroid Cancer Stem-Like Cells: From Microenvironmental Niches to Therapeutic Strategies.Journal of clinical medicine · 2021Review
- Selective inhibition of V600E-mutant BRAF gene induces apoptosis in thyroid carcinoma cell lines.Annals of surgical treatment and research · 2021Article
- Inflammatory Components of the Thyroid Cancer Microenvironment: An Avenue for Identification of Novel Biomarkers.Advances in experimental medicine and biology · 2021Article
- Prognosis of Macrophage Density in the Absence of Neutrophils in Differentiated Thyroid Cancer.The Journal of surgical research · 2020Article
- Identification of serum biomarker panel to differentiate malignant from benign thyroid nodules using multiplex bead assay.Journal of the Egyptian National Cancer Institute · 2020Article
- Multiplexing cytokine analysis: towards reducing sample volume needs in clinical diagnostics.The Analyst · 2019Article
- [Identification of key pathways and drug repurposing for anaplastic thyroid carcinoma by integrated bioinformatics analysis].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2018Article
- Role of Chemokines in Thyroid Cancer Microenvironment: Is CXCL8 the Main Player?Frontiers in endocrinology · 2018Review
- Multiple anti-tumor effects of Reparixin on thyroid cancer.Oncotarget · 2017Article
- Bioinformatics analysis of key genes and latent pathway interactions based on the anaplastic thyroid carcinoma gene expression profile.Oncology letters · 2017Article
- Diagnostic Accuracy of Contrast-Enhanced Ultrasound Enhancement Patterns for Thyroid Nodules.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved.Oncotarget · 2014Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum interleukin-8 (IL-8) and interferon-alpha (IFN-α) levels have been estimated from a total of 88 individuals of which 19 were disease-free healthy individuals, and 69 were patients with thyroid diseases: goitre (N = 21), autoimmune diseases (N = 16), and carcinomas (N = 32). Both IL-8 and IFN-α were significantly higher in all the patients as compared to healthy individuals. Serum IL-8 levels showed significant positive correlation with disease stage in thyroid cancer patients. Higher serum IL-8 levels were associated with advanced disease stage while no significant correlation was observed between serum IFN-α levels and any of the clinicopathological parameters. IL-8 and IFN-α significantly correlated with each other in anaplastic carcinoma patients. Finally concluding, monitoring the serum IL-8 and IFN-α levels can help differentiate patients with thyroid diseases from healthy individuals, and IL-8 seems to have a role in the pathogenesis of thyroid diseases and may represent a target for innovative diagnostic and therapeutic strategies.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.