ArticleInternational journal of Alzheimer's disease2011
Psychosis in Alzheimer's disease in the national Alzheimer's disease coordinating center uniform data set: clinical correlates and association with apolipoprotein e.
Article in International journal of Alzheimer's disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The Associations Between Neuropsychiatric Symptoms and Cognition in People with Dementia: A Systematic Review and Meta-Analysis.Neuropsychology review · 2024Pooled it
- Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease.Molecular psychiatry · 2021Pooled it
- Apolipoprotein E-ε4 allele predicts escalation of psychotic symptoms in late adulthood.Schizophrenia research · 2019Pooled it
- Genome-wide association study of Alzheimer's disease with psychotic symptoms.Molecular psychiatry · 2012Pooled it
- GWAS links APOE to neuropsychiatric symptoms in mild cognitive impairment and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Determining Whether Sex and Zygosity Modulates the Association between APOE4 and Psychosis in a Neuropathologically-Confirmed Alzheimer's Disease Cohort.Brain sciences · 2022Article
- Sex Modifies the Associations of APOEɛ4 with Neuropsychiatric Symptom Burden in Both At-Risk and Clinical Cohorts of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2022Article
- Genetic risk for schizophrenia and psychosis in Alzheimer disease.Molecular psychiatry · 2018Article
- Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease.Current Alzheimer research · 2018Article
- Transdiagnostic Extension of Delusions: Schizophrenia and Beyond.Schizophrenia bulletin · 2017Review
- Gender and Pathology-Specific Effect of Apolipoprotein E Genotype on Psychosis in Alzheimer's Disease.Current Alzheimer research · 2017Article
- Genetics of psychosis of Alzheimer disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Clinicopathological correlation of psychosis and brain vascular changes in Alzheimer's disease.Scientific reports · 2016Article
- Genetic variants associated with susceptibility to psychosis in late-onset Alzheimer's disease families.Neurobiology of aging · 2015Article
- Psychosis in Alzheimer's disease.Biological psychiatry · 2014Review
- Genetics of Psychosis in Alzheimer Disease.Current genetic medicine reports · 2014Article
- Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders.Journal of neurochemistry · 2013Review
- Genetic association between APOE*4 and neuropsychiatric symptoms in patients with probable Alzheimer's disease is dependent on the psychosis phenotype.Behavioral and brain functions : BBF · 2012Article
- TOMM40 poly-T repeat lengths, age of onset and psychosis risk in Alzheimer disease.Neurobiology of aging · 2011Article
- Neuropsychiatric symptoms and Apolipoprotein E: Associations with eventual Alzheimer's disease development.Archives of gerontology and geriatricsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Approximately 50% of late-onset Alzheimer's disease (AD) patients develop psychosis (AD+P), a heritable phenotype associated with more rapid cognitive decline. Prior studies conflict regarding whether apolipoprotein E (APOE) ϵ4 alleles are associated with AD+P, possibly due to small sample sizes, inconsistent diagnostic criteria, and different methodologies to assess psychosis. We used the National Alzheimer's Coordinating Center Uniform Data Set to evaluate the largest uniformly characterized sample of AD+P subjects studied to date for the association of APOE ϵ4 genotype, along with other demographic and clinical variables. Greater cognitive impairment and depressive symptoms were associated with AD+P, while the Caucasian race was protective. Neither APOE ϵ4 carrier status nor allele number was associated with psychosis. The AD+P phenotype is not associated with the APOE ϵ4 genotype. AD+P may represent a useful phenotype for the discovery of non-APOE ϵ4 genetic variation contributing to the risk of AD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.