ArticleMediators of inflammation2011
Immunomodulatory effects of aerobic training in obesity.
Article in Mediators of inflammation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Lymphocyte and dendritic cell response to a period of intensified training in young healthy humans and rodents: A systematic review and meta-analysis.Frontiers in physiology · 2022Pooled it
- Effects of aerobic training on markers of autophagy in the elderly.Age (Dordrecht, Netherlands) · 2016Trial
- Influence of High Polyphenol Beverage on Stress-Induced Platelet Activation.The journal of nutrition, health & aging · 2016Trial
- 12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis.Mediators of inflammation · 2016Trial
- The effects of exercise training in a weight loss lifestyle intervention on asthma control, quality of life and psychosocial symptoms in adult obese asthmatics: protocol of a randomized controlled trial.BMC pulmonary medicine · 2015Trial
- Role of Toll-like receptor 2 and 4 signaling pathways on the inflammatory response to resistance training in elderly subjects.Age (Dordrecht, Netherlands) · 2014Trial
- Manual therapy and exercise effects on inflammatory cytokines: a narrative overview.Frontiers in rehabilitation sciences · 2024Review
- Physical fitness status modulates the inflammatory proteins in peripheral blood and circulating monocytes: role of PPAR-gamma.Scientific reports · 2020Article
- Changes of post-operative peripheral blood dendritic cells in patients undergoing laparoscopy.Central-European journal of immunology · 2020Article
- Combined All-Extremity High-Intensity Interval Training Regulates Immunometabolic Responses through Toll-Like Receptor 4 Adaptors and A20 Downregulation in Obese Young Females.Obesity facts · 2020Article
- Aerobic but not Resistance Exercise Can Induce Inflammatory Pathways via Toll-Like 2 and 4: a Systematic Review.Sports medicine - open · 2017Review
- Comment on "the effect of a community-based, primary health care exercise program on inflammatory biomarkers and hormone levels".Mediators of inflammation · 2015Article
- Whole-body cryostimulation as an effective method of reducing low-grade inflammation in obese men.The journal of physiological sciences : JPS · 2013Article
- Modulation of dendritic cells and toll-like receptors by marathon running.European journal of applied physiology · 2012Article
- oxLDL downregulates the dendritic cell homing factors CCR7 and CCL21.Mediators of inflammation · 2012Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPhysical inactivity and obesity are independent risk factors for atherosclerosis. We analyzed the immunomodulatory capacity of 10-week intensified exercise training (ET) in obese and lean athletes. Markers of the innate immune response were investigated in obese (ONE: ET≤40 km/week) and lean athletes (LNE: ET≤40 km/week and LE: ET≥55 km/week).
methodsCirculating dendritic cells (DC) were analyzed by flow-cytometry for BDCA-1/-2-expression. TLR-2/-4/-7 and MyD88 were analyzed by RT-PCR and Western blot. Circulating oxLDL levels were analyzed by ELISA.
resultsBDCA-1 expression at baseline was lower in ONE compared to both other groups (ONE 0.15%; LNE 0.27%; LE 0.33%; P < .05), but significantly increased in ONE after training (+50%; P < .05). In contrast, BDCA-2 expression at baseline was higher in ONE (ONE 0.25%; LNE 0.11%; LE 0.09%; P < .05) and decreased in ONE after the 10-week training period (-27%; P < .05). Gene activations of TLR-4 and TLR-7 with corresponding protein increase were found for all three groups (P < .01/P < .05) compared to pre training. A reduction of oxLDL levels was seen in ONE (-61%; P < .05).
conclusionsIntensified exercise induces an increase of BDCA-1+ DCs and TLR-4/-7 in obese athletes. We hereby describe new immune modulatory effects, which-through regular aerobic exercise-modulate innate immunity and pro-inflammatory cytokines in obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.