Trial reportSleep2011
Comparative effects of two oral appliances on upper airway structure in obstructive sleep apnea.
Trial report in Sleep, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Clinical Practice Guideline for the Treatment of Obstructive Sleep Apnea and Snoring with Oral Appliance Therapy: An Update for 2015.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Pooled it
- Effects of mandibular advancement devices on upper airway dimensions in obstructive sleep apnea: responders versus non-responders.Clinical oral investigations · 2023Trial
- Comparisons of the effects of two types of titratable mandibular advancement devices on respiratory parameters and upper airway dimensions in patients with obstructive sleep apnea: a randomized controlled trial.Clinical oral investigations · 2023Trial
- Functional imaging improves patient selection for mandibular advancement device treatment outcome in sleep-disordered breathing: a prospective study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Trial
- The efficacy of a titrated tongue-stabilizing device on obstructive sleep apnea: a quasi-experimental study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Trial
- Randomized crossover study of tongue-retaining device and positive airway pressure for obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2020Trial
- Upper-Airway Collapsibility and Loop Gain Predict the Response to Oral Appliance Therapy in Patients with Obstructive Sleep Apnea.American journal of respiratory and critical care medicine · 2016Trial
- A combination appliance for obstructive sleep apnea: the effectiveness of mandibular advancement and tongue retention.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2012Trial
- Clinical Effectiveness of a Separated-Type Oral Appliance for Obstructive Sleep Apnea in Japanese Patients.Dentistry journal · 2026Article
- Surgical hyoid bone repositioning effects on mandibular advancement and upper airway collapsibility: an anesthetized rabbit model study.Frontiers in physiology · 2025Article
- The role of orthodontists in the multidisciplinary management of obstructive sleep apnea.Progress in orthodontics · 2024Review
- A mandibular advancement device associated with lingual control: a new treatment option for obstructive sleep apnea?Sleep & breathing = Schlaf & Atmung · 2024Article
- A Multicenter Prospective Study on the Use of a Mandibular Advancement Device in the Treatment of Obstructive Sleep Apnea.Dentistry journal · 2023Article
- Effectiveness of a Uniquely Designed Oral Appliance on Obstructive Sleep Apnea Control: A Pilot Study.European journal of dentistry · 2022Article
- Custom-Made Dual-Functional Oral Appliance for Management of Obstructive Sleep Apneic Completely Edentulous Patient.Cureus · 2021Article
- The Emerging Role of Drug-Induced Sleep Endoscopy in the Management of Obstructive Sleep Apnea.Clinical and experimental otorhinolaryngology · 2021Review
- A consideration of factors affecting palliative oral appliance effectiveness for obstructive sleep apnea: a scoping review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Assessment of Screening for Nasal Obstruction among Sleep Dentistry Outpatients with Obstructive Sleep Apnea.Dentistry journal · 2020Article
- The relationship between specific nasopharyngoscopic features and treatment deterioration with mandibular advancement devices: a prospective study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- More Than the Sum of the Respiratory Events: Personalized Medicine Approaches for Obstructive Sleep Apnea.American journal of respiratory and critical care medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesOral appliances are increasingly being used for treatment of obstructive sleep apnea (OSA). Mandibular advancement splint (MAS) mechanically protrudes the mandible, while the tongue stabilizing device (TSD) protrudes and holds the tongue using suction. Although both appliances can significantly improve or ameliorate OSA, their comparative effects on upper airway structure have not been investigated.
designCohort study.
settingSleep Investigation Unit. PATIENTS: 39 patients undergoing oral appliance treatment for OSA.
interventionsOSA patients underwent magnetic resonance imaging (MRI) of the upper airway during wakefulness at baseline and with MAS and TSD in randomized order. Treatment efficacy was determined by polysomnography in a subset of 18 patients. MEASUREMENTS AND
resultsUpper airway lumen and surrounding soft tissue structures were segmented using image analysis software. Upper airway dimensions and soft tissue centroid movements were determined. Both appliances altered upper airway geometry, associated with movement of the parapharyngeal fat pads away from the airway. TSD increased velopharyngeal lateral diameter to a greater extent (+0.35 ± 0.07 vs. +0.18 ± 0.05 cm; P<0.001) and also increased antero-posterior diameter with anterior displacement of the tongue (0.68 ± 0.04 cm; P<0.001) and soft palate (0.12 ± 0.03 cm; P<0.001). MAS resulted in significant anterior displacement of the tongue base muscles (0.35 ± 0.04 cm). TSD responders (AHI reduction ≥50%) increased velopharyngeal volume more than non-responders (+2.65 ± 0.9 vs. -0.44 ± 0.8 cm(3); P < 0.05). Airway structures did not differ between MAS responders and non-responders.
conclusionsThese results indicate that the patterns and magnitude of changes in upper airway structure differ between appliances. Further studies are warranted to evaluate the clinical relevance of these changes, and whether they can be used to predict treatment outcome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.