ArticleCurrent immunology reviews2011
Aging of the Innate Immune System: An Update.
Article in Current immunology reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed.
- Immunoinflammatory biomarkers for sepsis-associated acute kidney injury: a multicenter prospective cohort study.Immunity & ageing : I & A · 2026Article
- Network Rewiring in the Aging Immune System: From Chronic Inflammation to Age-Related Pathologies.Cells · 2026Review
- Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence.Metabolites · 2025Review
- Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle.Frontiers in immunology · 2025Review
- Modeling the CD8＋ T cell immune response to influenza infection in adult and aged mice.Journal of theoretical biology · 2024Article
- Age-dependent ventilator-induced lung injury: Mathematical modeling, experimental data, and statistical analysis.PLoS computational biology · 2024Article
- Geriatric Surgery Produces a Hypoactive Molecular Phenotype in the Monocyte Immune Gene Transcriptome.Journal of clinical medicine · 2023Article
- Hypoxic State of Cells and Immunosenescence: A Focus on the Role of the HIF Signaling Pathway.Biomedicines · 2023Review
- Endoplasmic Reticulum Stress in Elderly Patients with COVID-19: Potential of Melatonin Treatment.Viruses · 2023Review
- Ageing and Low-Level Chronic Inflammation: The Role of the Biological Clock.Antioxidants (Basel, Switzerland) · 2022Review
- Local immune cell contributions to fracture healing in aged individuals - A novel role for interleukin 22.Experimental & molecular medicine · 2022Article
- Why Does the Severity of COVID-19 Differ With Age?: Understanding the Mechanisms Underlying the Age Gradient in Outcome Following SARS-CoV-2 Infection.The Pediatric infectious disease journal · 2022Review
- Sympathetic nerve-adipocyte interactions in response to acute stress.Journal of molecular medicine (Berlin, Germany) · 2022Review
- A Review of the Potential Effects of Melatonin in Compromised Mitochondrial Redox Activities in Elderly Patients With COVID-19.Frontiers in nutrition · 2022Review
- Comparisons of Metastatic Patterns, Survival Outcomes and Tumor Immune Microenvironment Between Young and Non-Young Breast Cancer Patients.Frontiers in cell and developmental biology · 2022Article
- Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women.Scientific reports · 2021Article
- Article
- Claims and reasons about mild COVID-19 in children.New microbes and new infections · 2021Review
- Prevalence of Aminoglycoside Resistance and Aminoglycoside Modifying Enzymes inInfection and drug resistance · 2021Article
- Aging, But Not Sex and Genetic Diversity, Impacts the Pathobiology of Bacterial Endophthalmitis.Investigative ophthalmology & visual science · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The relationship between advanced age and immunologic deficits is becoming an area of rapidly advancing research. Many of the clinical hurdles in the elderly population result from dysregulation of the immune system leading to the inability of the elderly to swiftly combat infection and to the increased incidence of chronic disease states and autoimmune conditions. Herein, we address the crucial alterations in the innate immune system that occur with advancing age. Specifically, we discuss how the effects of advanced age may lead to functional changes in the neutrophil, macrophage, dendritic cell, natural killer cell, and natural killer T cell populations in human and murine models that translate into aberrant innate immune responses. Furthermore, we elucidate how these changes may contribute to documented deficits in adaptive immunity as well as the pathological conditions and the increased morbidity and mortality seen in the elderly population.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.