ArticleEpilepsy currents2011
Does acquired epileptogenesis in the immature brain require neuronal death.
Article in Epilepsy currents, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- PTEN deletion in the adult dentate gyrus induces epilepsy.Neurobiology of disease · 2024Article
- PTEN DELETION IN THE ADULT DENTATE GYRUS INDUCES EPILEPSY.bioRxiv : the preprint server for biology · 2024Article
- Ectopic expression of neuronal adenosine kinase, a biomarker in mesial temporal lobe epilepsy without hippocampal sclerosis.Neuropathology and applied neurobiology · 2023Article
- Background suppression of electrical activity is a potential biomarker of subsequent brain injury in a rat model of neonatal hypoxia-ischemia.Journal of neurophysiology · 2022Article
- Adenosine Kinase Isoforms in the Developing Rat Hippocampus after LiCl/Pilocarpine Status Epilepticus.International journal of molecular sciences · 2022Article
- The Protective Role of E-64d in Hippocampal Excitotoxic Neuronal Injury Induced by Glutamate in HT22 Hippocampal Neuronal Cells.Neural plasticity · 2021Article
- CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus.International journal of molecular medicine · 2020Article
- Epileptogenesis in neonatal brain.Seminars in fetal & neonatal medicine · 2018Review
- Long-Term Effects of Early Life Seizures on Endogenous Local Network Activity of the Mouse Neocortex.Frontiers in synaptic neuroscience · 2018Article
- Enduring Memory Impairments Provoked by Developmental Febrile Seizures Are Mediated by Functional and Structural Effects of Neuronal Restrictive Silencing Factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A novel, noninvasive, predictive epilepsy biomarker with clinical potential.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Neuronal degeneration is observed in multiple regions outside the hippocampus after lithium pilocarpine-induced status epilepticus in the immature rat.Neuroscience · 2013Article
- Chopping Out CHOP Chops the Fate of Neurons.Epilepsy currents · 2013Article
- One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death.Neuroscience bulletin · 2013Article
- The brain, seizures and epilepsy throughout life: understanding a moving target.Epilepsy currents · 2012Article
- Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic targets: a review.Journal of neuroscience research · 2012Review
- Novel animal models of pediatric epilepsy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis.PloS one · 2012Article
- Prospects for imaging-related biomarkers of human epileptogenesis: a critical review.Biomarkers in medicine · 2011Review
- Lithium pilocarpine-induced status epilepticus in postnatal day 20 rats results in greater neuronal injury in ventral versus dorsal hippocampus.Neuroscience · 2011Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Because epilepsy often occurs during development, understanding the mechanisms by which this process takes place (epileptogenesis) is important. In addition, the age-specificity of seizures and epilepsies of the neonatal, infancy, and childhood periods suggests that the processes and mechanisms that culminate in epilepsy might be age specific as well. Here we provide an updated review of recent and existing literature and discuss evidence that neuronal loss may occur during epileptogenesis in the developing brain, but is not required for the epileptogenic process. We speculate about the mechanisms for the resilience of neurons in immature limbic structures to epileptogenic insults, and propose that the type, duration and severity of these insults influence the phenomenology of the resulting spontaneous seizures.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.