ArticlePlastic and reconstructive surgery2011
Quantitative analysis of vascular response after mandibular fracture repair using microcomputed tomography with vessel perfusion.
Article in Plastic and reconstructive surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Temporal Pattern of micro-CT Angiography Vascular Parameters and VEGF mRNA Expression in Fracture Healing: a Radiograph and Molecular Comparison.European journal of dentistry · 2023Article
- Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization.NPJ Regenerative medicine · 2019Article
- Stem cells rejuvenate radiation-impaired vasculogenesis in murine distraction osteogenesis.Plastic and reconstructive surgery · 2015Article
- Quantification and characterization of radiation-induced changes to mandibular vascularity using micro-computed tomography.Annals of plastic surgery · 2014Article
- Stem cell therapy remediates reconstruction of the craniofacial skeleton after radiation therapy.Stem cells and development · 2013Article
- Validation of Histologic Bone Analysis Following Microfil Vessel Perfusion.Journal of histotechnology · 2012Article
- Bone regeneration in distraction osteogenesis demonstrates significantly increased vascularity in comparison to fracture repair in the mandible.The Journal of craniofacial surgery · 2012Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPoor healing after mandibular fracture repair can be a devastating morbidity with significant clinical consequences. Elucidating the vascular response after mandibular fracture may help determine potential areas for therapeutic interventions for nonunions. The authors performed microcomputed tomographic imaging after vessel perfusion to ascertain objective measures of vascular networks. They hypothesized that despite the haversian-based, highly cortical structure of the mandible, the vascular response after fracture healing will return to nearly normal levels soon after bony union, mirroring the results of endochondral, highly trabecular long bones.
methodsSprague-Dawley rats (n = 12) underwent mandibular osteotomy, and a 2.1-mm fixed gap was set. Animals were euthanized at 40 days after surgery and perfused with Microfil. Specimens underwent microcomputed tomographic analysis for stereologic vascular metrics. Data were compared with nonfractured controls (n = 5). Ninety-five percent confidence intervals and the independent samples t test (p < 0.05) were used to determine statistical differences.
resultsQuantitative measures for mandibular fracture versus control revealed similarities in the following vascular metrics: vessel volume fraction (0.028 percent versus 0.032 percent; 95 percent CI, -0.027 to 0.0169 percent), vessel number (0.497 mm(-1) versus 0.472 mm(-1); 95 percent CI, -0.884 to 0.975 mm(-1)), vessel thickness (0.052 mm versus 0.067 mm; 95 percent CI, -0.037 to 0.008 mm), and vessel separation (2.344 mm versus 2.081 mm; 95 percent CI, -0.752 to 1.278 mm).
conclusionsTo the authors' knowledge, this is the first study using microcomputed tomography after perfusion to analyze vascular response following mandibular fracture. Their findings establish quantitative similarities and qualitative differences in vascular response to fracture repair of the highly cortical mandible when compared with the highly trabecular long bone.
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