Evidence map›Paper›PMID 21460394›Full record

ArticleCancer prevention research (Philadelphia, Pa.)2011

Walking the walk from genes through telomere maintenance to cancer risk.

Elizabeth H Blackburn

Open access · hybridAbstract readComment
PubMed Publisher
In one paragraph

Article in Cancer prevention research (Philadelphia, Pa.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016
    Article
  5. Article
  6. Article
  7. Review
  8. Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. The BATTLE to personalize lung cancer prevention through reverse migration.Cancer prevention research (Philadelphia, Pa.) · 2011
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Elizabeth H BlackburnDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143-2200, USA. elizabeth.blackburn@ucsf.edu
University of California, San Francisco · US

Funding

Synergism of telomere maintenance and telomerase with cancer-promoting signalingR01CA096840 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BLACKBURN, ELIZABETH H · 2002 to 2016
$4.8M
NCI NIH HHS R01 CA096840
6 · The paper itself

Abstract

Recent studies have shown associations between human population single-nucleotide polymorphisms (SNP) and white blood cell telomere shortness; independently, telomere shortness has been associated with higher risks of various cancers. However, no single previous study simultaneously linked a given SNP both with telomere length and reduced risk of cancer. In this issue of the journal (beginning on page 514), Gu and colleagues report four new SNPs associated, in three cohorts, with telomere length. One of these SNPs predicted risk for bladder cancer, an effect partially mediated by telomere length. Interventions that could forestall telomere shortening should be explored for their potential to reduce cancer risks.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAnimalsHumansNeoplasmsRisk FactorsTelomereUrinary Bladder Neoplasms

Identifiers

PMID21460394
OpenAlexW2139470984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.