ReviewClinical infectious diseases : an official publication of the Infectious Diseases Society of America2011
Interpreting assays for the detection of Streptococcus pneumoniae.
Review in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 101 citations in OpenAlex.
- Clinical and Economic Burden of Pneumococcal Disease Due to Serotypes Contained in the 20-Valent Pneumococcal Conjugate Vaccine in the Adult Population in France.Open forum infectious diseases · 2026Article
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- Mitral valve replacement for isolated mitral valve endocarditis: A survival case of Austrian syndrome.IDCases · 2026Article
- Inter-platform agreement and diagnostic performance of the automated LIAISONFrontiers in microbiology · 2026Article
- No culture? No problem: Clinical utility and pitfalls of non-culture diagnostics for pneumococcal parapneumonic effusions.Frontiers in medicine · 2026Review
- Clinical and evidence-based considerations for choosing a pneumococcal conjugate vaccine in India: A narrative review.Human vaccines & immunotherapeutics · 2025Review
- Sputum metagenomics in bronchiectasis reveals pan-European variation: an EMBARC-BRIDGE study.The European respiratory journal · 2025Article
- Structure, Function, and Regulation of LytA: TheMicroorganisms · 2025Review
- Rapid detection ofFrontiers in cellular and infection microbiology · 2025Article
- Value of pneumococcal PCR in respiratory samples for exclusion of pneumococcal pneumonia.JAC-antimicrobial resistance · 2023Article
- Characteristics and local risk factors of community-acquired and health-care-associated Staphylococcus aureus pneumonia.Scientific reports · 2022Article
- Diagnostic detection of intended bacteria associated with respiratory tract infections among Kelantanese Malaysian Hajj pilgrims by a ready-to-use, thermostable multiplex PCR assay.Saudi journal of biological sciences · 2022Article
- Streptococcus pneumoniae colonization in health care professionals at a tertiary university pediatric hospital.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- Estimating population-based incidence of community-acquired pneumonia and acute otitis media in children and adults in Ontario and British Columbia using health administrative data, 2005-2018: a Canadian Immunisation Research Network (CIRN) study.BMJ open respiratory research · 2022Article
- Clinical management and outcomes of acute febrile illness in children attending a tertiary hospital in southern Ethiopia.BMC infectious diseases · 2022Article
- Association Between Procalcitonin and Antibiotics in Children With Community-Acquired Pneumonia.Hospital pediatrics · 2022Article
- Time Trend of the Sensitivity of the Pneumococcal Urinary Antigen Test for Diagnosing Pneumococcal Community-Acquired Pneumonia: An Analysis of 15-Year, Prospective Cohort Data.Infectious diseases and therapy · 2021Article
- Estimating the contribution of HIV-infected adults to household pneumococcal transmission in South Africa, 2016-2018: A hidden Markov modelling study.PLoS computational biology · 2021Article
- Diagnosis of Streptococcus pneumoniae infection using circulating antibody secreting cells.PloS one · 2021Article
- Differential diagnosis between the coronavirus disease 2019 and Streptococcus pneumoniae pneumonia by thin-slice CT features.Clinical imaging · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Streptococcus pneumoniae is both an aggressive pathogen and a normal part of the human respiratory microbiome. Clinicians and microbiologists have struggled to develop tests that can identify pneumococcal respiratory infection and accurately distinguish colonization from invasive disease. Molecular methods hold the promise of an improved ability to rapidly detect microorganisms in respiratory secretions and to make an accurate diagnosis; however, interpretation of diagnostic testing for S. pneumoniae remains problematic. Molecular assays, such as those targeting the pneumolysin gene, may cross-react with other streptococcal species, confounding detection and quantification. Assays that target the autolysin gene appear to be more specific. Even when accurately identified, however, the significance of S. pneumoniae DNA detected in clinical samples is difficult to determine. Here we will discuss the challenges faced in the interpretation of molecular testing for S. pneumoniae, and some strategies that might be used to improve our ability to diagnose pneumococcal respiratory infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.