ArticleRNA (New York, N.Y.)2011
Multiple mechanisms collaborate to repress nanos translation in the Drosophila ovary and embryo.
Article in RNA (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Direct observation of translational activation by a ribonucleoprotein granule.Nature cell biology · 2024Article
- Me31B: a key repressor in germline regulation and beyond.Bioscience reports · 2024Review
- Integrated multiplexed assays of variant effect reveal determinants of catechol-O-methyltransferase gene expression.Molecular systems biology · 2024Article
- The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos.Nucleic acids research · 2023Article
- Translational Control during Developmental Transitions.Cold Spring Harbor perspectives in biology · 2019Review
- Promiscuity in post-transcriptional control of gene expression: Drosophila sex-lethal and its regulatory partnerships.FEBS letters · 2017Review
- The Drosophila hnRNP F/H Homolog Glorund Uses Two Distinct RNA-Binding Modes to Diversify Target Recognition.Cell reports · 2017Article
- Poly(ADP-Ribosyl)ation of hnRNP A1 Protein Controls Translational Repression in Drosophila.Molecular and cellular biology · 2016Article
- Germ Plasm Biogenesis--An Oskar-Centric Perspective.Current topics in developmental biology · 2016Review
- Review
- PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane.Cell metabolism · 2015Article
- Repression of Gurken translation by a meiotic checkpoint in Drosophila oogenesis is suppressed by a reduction in the dose of eIF1A.Development (Cambridge, England) · 2014Article
- The biology of the germ line in echinoderms.Molecular reproduction and development · 2014Review
- Article
- Unscrambling butterfly oogenesis.BMC genomics · 2013Article
- Smaug/SAMD4A restores translational activity of CUGBP1 and suppresses CUG-induced myopathy.PLoS genetics · 2013Article
- microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein.EMBO reports · 2013Article
- mRNA localization and translational control in Drosophila oogenesis.Cold Spring Harbor perspectives in biology · 2012Review
- From cis-regulatory elements to complex RNPs and back.Cold Spring Harbor perspectives in biology · 2012Article
- RNA granules in germ cells.Cold Spring Harbor perspectives in biology · 2011Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Translational control of gene expression is essential for development in organisms that rely on maternal mRNAs. In Drosophila, translation of maternal nanos (nos) mRNA must be restricted to the posterior of the early embryo for proper patterning of the anterior-posterior axis. Spatial control of nos translation is coordinated through the localization of a small subset of nos mRNA to the posterior pole late in oogenesis, activation of this localized mRNA, and repression of the remaining unlocalized nos mRNA throughout the bulk cytoplasm. Translational repression is mediated by the interaction of a cis-acting element in the nos 3' untranslated region with two proteins, Glorund (Glo) and Smaug (Smg), that function in the oocyte and embryo, respectively. The mechanism of Glo-dependent repression is unknown. Previous work suggests that Smg represses translation initiation but this model is not easily reconciled with evidence for polysome association of repressed nos mRNA. Using an in vitro translation system, we have decoupled translational repression of nos imposed during oogenesis from repression during embryogenesis. Our results suggest that both Glo and Smg regulate translation initiation, but by different mechanisms. Furthermore, we show that, during late oogenesis, nos translation is also repressed post-initiation and provide evidence that Glo mediates this event. This post-initiation block is maintained into embryogenesis during the transition to Smg-dependent regulation. We propose that the use of multiple modes of repression ensures inactivation of nos RNA that is translated at earlier stages of oogenesis and maintenance of this inactivate state throughout late oogenesis into embryogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.