ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Cytotoxic T Cell-Derived Granzyme B Is Increased in SevereFrontiers in immunology · 2019Trial
- Liver sinusoid constraints make random search of CD8 T cells for Plasmodium parasites efficient.bioRxiv : the preprint server for biology · 2025Article
- Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination.PLoS pathogens · 2025Article
- Heterogeneity in killing efficacy of individual effector CD8Proceedings. Biological sciences · 2023Article
- Memory CD8+ T cell-mediated protection against liver-stage malaria.Immunological reviews · 2023Review
- Mathematical Modeling to Guide Experimental Design: T Cell Clustering as a Case Study.Bulletin of mathematical biology · 2022Article
- Using two phases of the CD4 T cell response to blood-stage murine malaria to understand regulation of systemic immunity and placental pathology in Plasmodium falciparum infection.Immunological reviews · 2020Review
- T cell-mediated immunity to malaria.Nature reviews. Immunology · 2019Review
- Sendai Virus Mucosal Vaccination Establishes Lung-Resident Memory CD8 T Cell Immunity and Boosts BCG-Primed Protection against TB in Mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Article
- Immune Signature of Enhanced Functional Avidity CD8Scientific reports · 2017Article
- Protective immunity to liver-stage malaria.Clinical & translational immunology · 2016Review
- Discriminating Protective from Nonprotective Plasmodium-Specific CD8+ T Cell Responses.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Plasmodium cellular effector mechanisms and the hepatic microenvironment.Frontiers in microbiology · 2015Review
- Measurement of the T Cell Response to Preerythrocytic Vaccination in Mice.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Diet-induced obesity does not impact the generation and maintenance of primary memory CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Memory T cells maintain protracted protection against malaria.Immunology letters · 2014Review
- Correlates of protective immunity following whole sporozoite vaccination against malaria.Immunologic research · 2014Review
- TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- CD8 T-cell-mediated protection against liver-stage malaria: lessons from a mouse model.Frontiers in microbiology · 2014Review
- Analysis of lymphocytes in patients with Plasmodium vivax malaria and its relation to the annexin-A1 and IL-10.Malaria journal · 2013Article
Corrections and comments
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3 authors.
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Abstract
Plasmodium infections are responsible for millions of cases of malaria and ∼1 million deaths annually. Recently, we showed that sterile protection (95%) in BALB/c mice required Plasmodium berghei circumsporozoite protein (CS(252-260))-specific memory CD8 T cells exceeding a threshold of 1% of all PBLs. Importantly, it is not known if Plasmodium species affect the threshold of CS-specific memory CD8 T cells required for protection. Furthermore, C57BL/6 mice immunized with radiation-attenuated parasites are more difficult to protect against Plasmodium sporozoite challenge than similarly immunized BALB/c mice; however, it is not known whether this is the result of different CD8 T cell specificity, functional attributes of CD8 T cells, or mouse strain-specific factors expressed in nonhematopoietic cells. In this article, we show that more CS-specific memory CD8 T cells are required for protection against P. yoelii sporozoite challenge than for protection against P. berghei sporozoite challenge. Furthermore, P. berghei CS(252)-specific CD8 T cells exhibit reduced protection against P. berghei sporozoite challenge in the context of C57BL/6 and C57BL/10 non-MHC-linked genes in CB6F1 and B10.D2 mice, respectively. Generation and immunization of reciprocal chimeric mice between BALB/c and B10.D2 strains revealed that B10 background factors expressed by nonhematopoietic cells increased the threshold required for protection through a CD8 T cell-extrinsic mechanism. Finally, reduced CS-specific memory CD8 T cell protection in P. yoelii-infected BALB/c or P. berghei-infected B10.D2 mice correlated with increased rates of Plasmodium amplification in the liver. Thus, both Plasmodium species and strain-specific background genes in nonhematopoietic cells determine the threshold of memory CD8 T cells required for protection.
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