ArticleAmerican journal of physiology. Heart and circulatory physiology2011
Effect of dietary omega-3 fatty acids on the heart rate and the heart rate variability responses to myocardial ischemia or submaximal exercise.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Effects of MarineNutrients · 2018Trial
- Fish oil and neurovascular control in humans.American journal of physiology. Heart and circulatory physiology · 2012Trial
- Fish oil supplements in patients with chronic kidney disease.Clinical kidney journal · 2026Review
- The Effects of Omega-3 Supplementation on the Omega-3 Index and Quality of Life and Pain Scores in Dogs.Animals : an open access journal from MDPI · 2024Article
- Capillary Blood Docosahexaenoic Acid Levels Predict Electrocardiographic Markers in a Sample Population of Premenopausal Women.Journal of clinical medicine · 2024Article
- Moving average and standard deviation thresholding (MAST): a novel algorithm for accurate R-wave detection in the murine electrocardiogram.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Contraction-relaxation coupling is unaltered by exercise training and infarction in isolated canine myocardium.The Journal of general physiology · 2021Article
- Direct evidence of bradycardic effect of omega-3 fatty acids acting on nucleus ambiguus.Neuroscience letters · 2020Article
- Article
- Heart-rate variability: a biomarker to study the influence of nutrition on physiological and psychological health?Behavioural pharmacology · 2018Review
- Effect of exercise training and myocardial infarction on force development and contractile kinetics in isolated canine myocardium.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Cardiac physiology and clinical efficacy of dietary fish oil clarified through cellular mechanisms of omega-3 polyunsaturated fatty acids.European journal of applied physiology · 2014Review
- Association of heart rate variability and inflammatory response in patients with cardiovascular diseases: current strengths and limitations.Frontiers in physiology · 2013 · on this mapArticle
- Effect of dietary omega-3 polyunsaturated Fatty acids on heart rate and heart rate variability in animals susceptible or resistant to ventricular fibrillation.Frontiers in physiology · 2012Article
- Reduction of heart rate by omega-3 fatty acids and the potential underlying mechanisms.Frontiers in physiology · 2012Article
- Fatty Acid use in Diving Mammals: More than Merely Fuel.Frontiers in physiology · 2012Article
- Omega-3 Fatty acids: anti-arrhythmic, pro-arrhythmic, or both?Frontiers in physiology · 2012Article
- Omega-3 polyunsaturated Fatty acids and heart rate variability.Frontiers in physiology · 2011Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The consumption of omega-3 polyunsaturated fatty acids (n-3 PUFAs) has been reported to decrease resting heart rate (HR) and increase heart rate variability (HRV). However, the effects of n-3 PUFAs on these variables in response to a physiological stress (e.g., exercise or acute myocardial ischemia), particularly in postmyocardial infarction (MI) patients, are unknown. Therefore, HR and HRV (high frequency and total R-R interval variability) were evaluated at rest, during submaximal exercise, and during a 2-min coronary artery occlusion at rest and before and 3 mo after n-3 PUFA treatment in dogs with healed MI (n = 59). The dogs were randomly assigned to either placebo (1 g/day corn oil, n = 19) or n-3 PUFA supplement (docosahexaenoic acid + eicosapentaenoic acid ethyl esters; 1 g/day, n = 6; 2 g/day, n = 12; or 4 g/day, n = 22) groups. The treatment elicited significant (P < 0.01) dose-dependent increases in right atrial n-3 PUFA levels but dose-independent reductions in resting HR and increases in resting HRV. In contrast, n-3 PUFAs did not attenuate the large changes in HR or HRV induced by either the coronary occlusion or submaximal exercise. These data demonstrate that dietary n-3 PUFA decreased resting (i.e., preexercise or preocclusion) HR and increased resting HRV but did not alter the cardiac response to physiologic challenges.
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Registered trials
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