ArticleApplied and environmental microbiology2011
Diversity, evolution, and functionality of clustered regularly interspaced short palindromic repeat (CRISPR) regions in the fire blight pathogen Erwinia amylovora.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 119 citations in OpenAlex.
- Pathogenicity and virulence ofVirulence · 2026Review
- Screening and genomic identification of the bacterial pathogens from an apple orchard in Kazakhstan.PeerJ · 2026Article
- Development of strain specific simple sequence repeats and assessment of genetic diversity in Erwinia amylovora from marker selection to phylogenetic analysis.Scientific reports · 2025Article
- Genetic Diversity and Genotype Distribution of Erwinia amylovora in Korea.The plant pathology journal · 2025Article
- Intraspecific diversity of Erwinia amylovora strains from northern Algeria.BMC microbiology · 2024Article
- Phage Mediated Biocontrol: A Promising Green Solution for Sustainable Agriculture.Indian journal of microbiology · 2024Review
- Fire blight cases in Almaty Region of Kazakhstan in the proximity of wild apple distribution area.Journal of plant pathology : an international journal of the Italian Phytopathological Society · 2024Article
- Epidemiological description of fire blight introduction patterns to Central Asia and the Caucasus region based on CRISPR spacer typing and genome analysis.Phytopathology research · 2024Article
- Novel approach toward the understanding of genetic diversity based on the two types of amino acid repeats in Erwinia amylovora.Scientific reports · 2023Article
- CRISPR-Cas systems: role in cellular processes beyond adaptive immunity.Folia microbiologica · 2022Review
- A complete twelve-gene deletion null mutant reveals that cyclic di-GMP is a global regulator of phase-transition and host colonization in Erwinia amylovora.PLoS pathogens · 2022Article
- Function and Application of the CRISPR-Cas System in the Plant PathogenApplied and environmental microbiology · 2022Article
- Variability within a clonal population ofPeerJ · 2022Article
- Evaluation of Three Antimicrobial Peptides Mixtures to Control the Phytopathogen Responsible for Fire Blight Disease.Plants (Basel, Switzerland) · 2021Article
- Comprehensive Molecular Dissection ofInternational journal of molecular sciences · 2021Article
- CRISPR genotyping as complementary tool for epidemiological surveillance of Erwinia amylovora outbreaks.PloS one · 2021Article
- Bacteriophage Usage for Bacterial Disease Management and Diagnosis in Plants.The plant pathology journal · 2020Review
- High Synteny and Sequence Identity between Genomes ofMicroorganisms · 2020Article
- Mechanistic insights into host adaptation, virulence and epidemiology of the phytopathogen Xanthomonas.FEMS microbiology reviews · 2020Review
- Molecular Epidemiology ofFrontiers in microbiology · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clustered regularly interspaced short palindromic repeat (CRISPR)/Cas system confers acquired heritable immunity against mobile nucleic acid elements in prokaryotes, limiting phage infection and horizontal gene transfer of plasmids. In CRISPR arrays, characteristic repeats are interspersed with similarly sized nonrepetitive spacers derived from transmissible genetic elements and acquired when the cell is challenged with foreign DNA. New spacers are added sequentially and the number and type of CRISPR units can differ among strains, providing a record of phage/plasmid exposure within a species and giving a valuable typing tool. The aim of this work was to investigate CRISPR diversity in the highly homogeneous species Erwinia amylovora, the causal agent of fire blight. A total of 18 CRISPR genotypes were defined within a collection of 37 cosmopolitan strains. Strains from Spiraeoideae plants clustered in three major groups: groups II and III were composed exclusively of bacteria originating from the United States, whereas group I generally contained strains of more recent dissemination obtained in Europe, New Zealand, and the Middle East. Strains from Rosoideae and Indian hawthorn (Rhaphiolepis indica) clustered separately and displayed a higher intrinsic diversity than that of isolates from Spiraeoideae plants. Reciprocal exclusion was generally observed between plasmid content and cognate spacer sequences, supporting the role of the CRISPR/Cas system in protecting against foreign DNA elements. However, in several group III strains, retention of plasmid pEU30 is inconsistent with a functional CRISPR/Cas system.
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