Evidence map›Paper›PMID 21460015›Full record

ArticleThe American journal of tropical medicine and hygiene2011

Serologic diagnosis of human Taenia solium cysticercosis by using recombinant and synthetic antigens in QuickELISA™.

Yeuk-Mui Lee, Sukwan Handali, Kathy Hancock, Sowmya Pattabhi, Victor A Kovalenko, Andrew Levin, Silvia Rodriguez, Sehching Lin, Christina M Scheel, Armando E Gonzalez and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
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  5. Article
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  7. Article
  8. Review
  9. Article
  10. Article
  11. Laboratory Diagnosis of Neurocysticercosis (Taenia solium).Journal of clinical microbiology · 2018
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Taenia solium Taeniasis and Cysticercosis in Southeast Asia.The American journal of tropical medicine and hygiene · 2016
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Yeuk-Mui LeeDivision of Parasitic Diseases and Malaria, and Scientific Resource Program, Coordinating Center for Infectious Diseases, Center for Global Health, Centers for Diseases Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA. ylee@cdc.gov
Sukwan Handali
Kathy Hancock
Sowmya Pattabhi
Victor A Kovalenko
Andrew Levin
Silvia Rodriguez
Sehching Lin
Christina M Scheel
Armando E Gonzalez
Robert H Gilman
Hector H Garcia
Victor C W Tsang
Johns Hopkins University · USUniversidad Peruana Cayetano Heredia · PEDivision of Parasitic Diseases and Malaria · USGeorgia State University · US

Funding

Peptide-Based Serodiagnostic Test for CysticercosisR43AI064988 · NIAID · IMMUNETICS, INC. · PI KOVALENKO, VICTOR A · 2005 to 2005
$136k
NIAID NIH HHS 1R43AI64988-01NIAID NIH HHS R43 AI064988PHS HHS 2R44A1064988-02Wellcome Trust 091077
6 · The paper itself

Abstract

Diagnosis of Taenia solium cysticercosis is an important component in the control and elimination of cysticercosis and taeniasis. New detection assays using recombinant and synthetic antigens originating from the lentil lectin-purified glycoproteins (LLGPs) of T. solium cysticerci were developed in a QuickELISA™ format. We analyzed a panel of 474 serum samples composed of 108 serum samples from donors with two or more viable cysts, 252 serum samples from persons with other parasitic infections, and 114 serum samples from persons with no documented illnesses. The sensitivities and specificities of T24H QuickELISA™, GP50 QuickELISA™, and Ts18var1 QuickELISA™ were 96.3% and 99.2%, 93.5% and 98.6%, and 89.8% and 96.4%, respectively, for detecting cases with multiple, viable cysts. T24H QuickELISA™ performs best among the three assays, and has sensitivity and specificity values comparable to those of the LLGP enzyme-linked immunosorbent blot. The QuickELISA™ are simple, rapid quantitative methods for detecting antibodies specific for T. solium cysticerci antigens.

Indexed as

Taenia soliumAnimalsAntigens, HelminthCysticercosisEnzyme-Linked Immunosorbent AssayHumansSensitivity and SpecificitySerologic TestsAntigens, Helminth

Identifiers

PMID21460015
PMCPMC3062454
OpenAlexW2120435399

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.