ArticleThe Journal of infectious diseases2011
Substantially reduced pre-patent parasite multiplication rates are associated with naturally acquired immunity to Plasmodium falciparum.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01.The Journal of infectious diseases · 2016Trial
- Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults.Science translational medicine · 2015Trial
- Antibody and T-cell responses associated with experimental human malaria infection or vaccination show limited relationships.Immunology · 2015Trial
- Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909.PloS one · 2011Trial
- Controlled human malaria infection: overview and potential application in the evaluation of transmission-blocking interventions in malaria-endemic areas.Malaria journal · 2025Review
- Evidence for exposure dependent carriage of malaria parasites across the dry season: modelling analysis of longitudinal data.Malaria journal · 2023Article
- A systematic review and meta-analysis on sub-microscopicThe Lancet regional health. Southeast Asia · 2022Article
- Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination.Med (New York, N.Y.) · 2021Article
- Recent Molecular Assessment of Plasmodium vivax and Plasmodium falciparum Asymptomatic Infections in Botswana.The American journal of tropical medicine and hygiene · 2021Article
- Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance.Antimicrobial agents and chemotherapy · 2021Article
- Extent and Dynamics of Polymorphism in the Malaria Vaccine CandidateThe American journal of tropical medicine and hygiene · 2018Article
- Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria.Open forum infectious diseases · 2017Article
- Time-to-infection by Plasmodium falciparum is largely determined by random factors.BMC medicine · 2015Article
- Asymptomatic malaria infections: detectability, transmissibility and public health relevance.Nature reviews. Microbiology · 2014Review
- Enantiomerically pure amino-alcohol quinolines: in vitro anti-malarial activity in combination with dihydroartemisinin, cytotoxicity and in vivo efficacy in a Plasmodium berghei mouse model.Malaria journal · 2014Article
- A nested real-time PCR assay for the quantification of Plasmodium falciparum DNA extracted from dried blood spots.Malaria journal · 2014Article
- Decreased growth rate of P. falciparum blood stage parasitemia with age in a holoendemic population.The Journal of infectious diseases · 2014Article
- In vitro and in vivo combination of cepharanthine with anti-malarial drugs.Malaria journal · 2014Article
- Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection.Frontiers in microbiology · 2014Article
- Pharmacokinetic and pharmacodynamic considerations in antimalarial dose optimization.Antimicrobial agents and chemotherapy · 2013Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Naturally acquired immunity to Plasmodium falciparum's asexual blood stage reduces parasite multiplication at microscopically detectable densities. The effect of natural immunity on initial prepatent parasite multiplication during the period following a new infection has been uncertain, contributing to doubt regarding the utility of experimental challenge models for blood-stage vaccine trials. Here we present data revealing that parasite multiplication rates during the initial prepatent period in semi-immune Gambian adults are substantially lower than in malaria-naive participants. This supports the view that a blood-stage vaccine capable of emulating the disease-reducing effect of natural immunity could achieve a detectable effect during the prepatent period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.